pH值对壳聚糖与三聚磷酸钠交联作用的研究：技术札记
Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: a technical note.
作者信息
Bhumkar Devika R, Pokharkar Varsha B
机构信息
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune-411038, Maharashtra State, India.
出版信息
AAPS PharmSciTech. 2006 Jun 2;7(2):E50. doi: 10.1208/pt070250.
Abstract
The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity.
摘要
用于形成交联壳聚糖颗粒的离子凝胶法可以通过调节TPP的pH值轻松地从离子交联转变为去质子化。壳聚糖在较低pH值下与TPP进行离子交联，在较高pH值下通过去质子化机制交联。交联壳聚糖的溶胀行为似乎取决于TPP的pH值。离子交联的壳聚糖表现出更高的溶胀能力。因此，可以定制交联壳聚糖的性质，以在交联密度、结晶度和亲水性方面获得所需的性能。
相似文献
1
Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: a technical note.pH值对壳聚糖与三聚磷酸钠交联作用的研究：技术札记
AAPS PharmSciTech. 2006 Jun 2;7(2):E50. doi: 10.1208/pt070250.
2
Formation mechanism of monodisperse, low molecular weight chitosan nanoparticles by ionic gelation technique.采用离子凝胶技术制备单分散、低分子量壳聚糖纳米粒子的形成机制。
Colloids Surf B Biointerfaces. 2012 Feb 1;90:21-7. doi: 10.1016/j.colsurfb.2011.09.042. Epub 2011 Oct 2.
3
Insight on the formation of chitosan nanoparticles through ionotropic gelation with tripolyphosphate.通过三聚磷酸与壳聚糖的离子凝胶化形成壳聚糖纳米粒子的研究进展。
Mol Pharm. 2012 Oct 1;9(10):2856-62. doi: 10.1021/mp300162j. Epub 2012 Sep 4.
4
Development of chitosan-tripolyphosphate fibers through pH dependent ionotropic gelation.通过依赖 pH 值的离子凝胶化方法制备壳聚糖-三聚磷酸盐水凝胶纤维。
Carbohydr Res. 2011 Nov 29;346(16):2582-8. doi: 10.1016/j.carres.2011.08.028. Epub 2011 Sep 1.
5
[Preparation of basic fibroblast growth factor chitosan microsphere and its properties].碱性成纤维细胞生长因子壳聚糖微球的制备及其性质
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2012 Aug;26(8):989-92.
6
Moulded cross-linked chitosan matrix systems for controlled drug release.用于控制药物释放的模制交联壳聚糖基质系统。
Pharm Dev Technol. 2011 Aug;16(4):295-301. doi: 10.3109/10837451003664107. Epub 2010 Mar 9.
7
Ionotropic cross-linked chitosan microspheres for controlled release of ampicillin.用于氨苄西林控释的离子型交联壳聚糖微球。
Int J Pharm. 2006 Apr 7;312(1-2):166-73. doi: 10.1016/j.ijpharm.2006.01.043. Epub 2006 Feb 23.
8
Chitosan microparticle preparation for controlled drug release by response surface methodology.采用响应面法制备用于药物控释的壳聚糖微粒
J Microencapsul. 2003 Nov-Dec;20(6):791-7. doi: 10.1080/02652040310001600514.
9
Ultrafine chitosan nanoparticles as an efficient nucleic acid delivery system targeting neuronal cells.超细微壳聚糖纳米粒作为一种靶向神经元细胞的高效核酸传递系统。
Drug Dev Ind Pharm. 2009 Jun;35(6):719-26. doi: 10.1080/03639040802526789.
10
Chitosan/carrageenan nanoparticles: effect of cross-linking with tripolyphosphate and charge ratios.壳聚糖/卡拉胶纳米粒子：与三聚磷酸钠交联和电荷比的影响。
Carbohydr Polym. 2012 Jun 5;89(1):282-9. doi: 10.1016/j.carbpol.2012.03.010. Epub 2012 Mar 8.
引用本文的文献
1
Chitosan Nanoparticles: Approaches to Preparation, Key Properties, Drug Delivery Systems, and Developments in Therapeutic Efficacy.壳聚糖纳米颗粒：制备方法、关键特性、药物递送系统及治疗效果的进展
AAPS PharmSciTech. 2025 Apr 17;26(5):108. doi: 10.1208/s12249-025-03100-z.
2
Adsorption kinetics and mechanisms of nano chitosan coated cotton fiber for the removal of heavy metals from industrial effluents.纳米壳聚糖包覆棉纤维对工业废水中重金属的吸附动力学及机理
Heliyon. 2025 Feb 22;11(4):e42932. doi: 10.1016/j.heliyon.2025.e42932. eCollection 2025 Feb 28.
3
Chitosan as a Plurivalent Biopolymer in Nanodelivery Systems.壳聚糖作为纳米递送系统中的多价生物聚合物
Polymers (Basel). 2025 Feb 20;17(5):558. doi: 10.3390/polym17050558.
4
Uptake and Inhibition of P-Glycoprotein-Mediated Efflux Evaluation of Encapsulated Methotrexate Chitosan and Hypromellose Phthalate Nanoparticles for Potential Glioblastoma Treatment.用于潜在胶质母细胞瘤治疗的包封甲氨蝶呤壳聚糖和邻苯二甲酸羟丙甲纤维素纳米颗粒的P-糖蛋白介导的外排摄取与抑制评估
Pharmaceutics. 2025 Feb 12;17(2):239. doi: 10.3390/pharmaceutics17020239.
5
Preparation and Properties of Glycerohydrogels Based on Silicon Tetraglycerolate, Chitosan Hydrochloride and Glucomannan.基于四甘油基硅、盐酸壳聚糖和葡甘露聚糖的甘油水凝胶的制备及性能
Gels. 2025 Feb 2;11(2):103. doi: 10.3390/gels11020103.
6
Cell Membrane- and Extracellular Vesicle-Coated Chitosan Methacrylate-Tripolyphosphate Nanoparticles for RNA Delivery.用于RNA递送的细胞膜和细胞外囊泡包被的甲基丙烯酸壳聚糖-三聚磷酸纳米颗粒
Int J Mol Sci. 2024 Dec 23;25(24):13724. doi: 10.3390/ijms252413724.
7
Dual Antimicrobial Activity of HTCC and Its Nanoparticles: A Synergistic Approach for Antibacterial and Antiviral Applications Through Combined In Silico and In Vitro Studies.HTCC及其纳米颗粒的双重抗菌活性：通过计算机模拟和体外研究相结合的协同方法用于抗菌和抗病毒应用。
Polymers (Basel). 2024 Oct 25;16(21):2999. doi: 10.3390/polym16212999.
8
Advances in Chitosan-Based Smart Hydrogels for Colorectal Cancer Treatment.用于结直肠癌治疗的基于壳聚糖的智能水凝胶的研究进展
Pharmaceuticals (Basel). 2024 Sep 25;17(10):1260. doi: 10.3390/ph17101260.
9
Chitosan/Hesperidin Nanoparticles for Sufficient, Compatible, Antioxidant, and Antitumor Drug Delivery Systems.用于充足、兼容、抗氧化和抗肿瘤药物递送系统的壳聚糖/橙皮苷纳米颗粒
Pharmaceuticals (Basel). 2024 Jul 29;17(8):999. doi: 10.3390/ph17080999.
10
Investigation of delivery mechanism of curcumin loaded in a core of zein with a double-layer shell of chitosan and alginate.对负载于玉米醇溶蛋白核心且具有壳聚糖和海藻酸钠双层外壳的姜黄素递送机制的研究。
Heliyon. 2024 Jun 19;10(13):e33205. doi: 10.1016/j.heliyon.2024.e33205. eCollection 2024 Jul 15.
本文引用的文献
1
Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.用于生物医学应用的共价和离子交联壳聚糖水凝胶的结构与相互作用
Eur J Pharm Biopharm. 2004 Jan;57(1):19-34. doi: 10.1016/s0939-6411(03)00161-9.
2
Chitosan microparticles for mucosal vaccination against diphtheria: oral and nasal efficacy studies in mice.用于白喉黏膜疫苗接种的壳聚糖微粒：小鼠口服和鼻内免疫效果研究
Vaccine. 2003 Mar 28;21(13-14):1400-8. doi: 10.1016/s0264-410x(02)00686-2.
3
Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles.壳聚糖分子结构对壳聚糖纳米颗粒蛋白质递送特性的影响。
Int J Pharm. 2003 Jan 2;250(1):215-26. doi: 10.1016/s0378-5173(02)00548-3.
4
Chitosan for mucosal vaccination.用于黏膜疫苗接种的壳聚糖。
Adv Drug Deliv Rev. 2001 Nov 5;52(2):139-44. doi: 10.1016/s0169-409x(01)00197-1.
5
Chitosan and its derivatives in mucosal drug and vaccine delivery.壳聚糖及其衍生物在黏膜药物和疫苗递送中的应用。
Eur J Pharm Sci. 2001 Oct;14(3):201-7. doi: 10.1016/s0928-0987(01)00172-5.
6
Structural characterization of phosphorylated chitosan and their applications as effective additives of calcium phosphate cements.磷酸化壳聚糖的结构表征及其作为磷酸钙骨水泥有效添加剂的应用
Biomaterials. 2001 Aug;22(16):2247-55. doi: 10.1016/s0142-9612(00)00413-0.
7
Chitosan: a unique polysaccharide for drug delivery.壳聚糖：一种用于药物递送的独特多糖。
Drug Dev Ind Pharm. 1998 Nov;24(11):979-93. doi: 10.3109/03639049809089942.
8
Chitosan and its use as a pharmaceutical excipient.壳聚糖及其作为药物赋形剂的用途。
Pharm Res. 1998 Sep;15(9):1326-31. doi: 10.1023/a:1011929016601.
9
Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines.壳聚糖及壳聚糖/环氧乙烷-环氧丙烷嵌段共聚物纳米颗粒作为蛋白质和疫苗的新型载体
Pharm Res. 1997 Oct;14(10):1431-6. doi: 10.1023/a:1012128907225.
Zotero 插件