Bhumkar Devika R, Pokharkar Varsha B
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune-411038, Maharashtra State, India.
AAPS PharmSciTech. 2006 Jun 2;7(2):E50. doi: 10.1208/pt070250.
The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity.
用于形成交联壳聚糖颗粒的离子凝胶法可以通过调节TPP的pH值轻松地从离子交联转变为去质子化。壳聚糖在较低pH值下与TPP进行离子交联，在较高pH值下通过去质子化机制交联。交联壳聚糖的溶胀行为似乎取决于TPP的pH值。离子交联的壳聚糖表现出更高的溶胀能力。因此，可以定制交联壳聚糖的性质，以在交联密度、结晶度和亲水性方面获得所需的性能。
