Furukawa Y, Yoshikawa H, Yachie A, Yamada M
Department of Neurology and Neurobiology of Aging, Graduate School of Medical Science, Kanazawa University, Japan.
Eur J Neurol. 2006 Jun;13(6):655-8. doi: 10.1111/j.1468-1331.2006.01392.x.
We report two female patients with neuromyelitis optica (NMO, Devic's syndrome) following or coincidental with myasthenia gravis (MG). Their illnesses were characterized by subacute myelitis with optic neuritis, high serum levels of muscle acetylcholine receptor antibody, and autoimmune thyroid disease. Both patients fulfilled the clinical criteria of NMO, however, NMO-IgG, autoantibody against aquaporin-4 water channel, was absent from their sera. Both NMO and MG are relatively rare diseases. The considerable coincidence of these two disorders suggests that there is a subgroup of patients with NMO having a common immunological pathogenesis with MG.
我们报告了两名女性患者，她们在重症肌无力（MG）之后或与之同时发生了视神经脊髓炎（NMO，德维克综合征）。她们的病情特点为伴有视神经炎的亚急性脊髓炎、血清中肌肉乙酰胆碱受体抗体水平升高以及自身免疫性甲状腺疾病。两名患者均符合NMO的临床标准，然而，她们的血清中不存在针对水通道蛋白4水通道的自身抗体NMO-IgG。NMO和MG都是相对罕见的疾病。这两种疾病的显著巧合表明，存在一部分NMO患者与MG具有共同的免疫发病机制。
