Pritchard M A, Baker E, Whitmore S A, Sutherland G R, Idzerda R L, Park L S, Cosman D, Jenkins N A, Gilbert D J, Copeland N G
Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.
Genomics. 1991 Jul;10(3):801-6. doi: 10.1016/0888-7543(91)90466-r.
The chromosomal location of both the human and the mouse interleukin-4 receptor (IL4R) genes have been determined. The human gene was localized to 16p11.2-16p12.1 by in situ hybridization and confirmed by Southern blot analysis of DNA from a panel of mouse-human hybrid somatic cell lines. The mouse homolog was positioned in the distal region of chromosome 7 by interspecific backcross analysis. The results suggest that the IL4R locus is unlinked to other members of the hematopoietin receptor family. Interestingly, the position on human chromosome 16 suggests that the IL4R may be a candidate for rearrangements, as 12;16 translocations are often associated with myxoid liposarcomas.
人类和小鼠白细胞介素-4受体（IL4R）基因的染色体定位均已确定。通过原位杂交将人类基因定位到16p11.2 - 16p12.1，并通过对一组小鼠-人类杂交体细胞系的DNA进行Southern印迹分析得以证实。通过种间回交分析将小鼠同源基因定位在染色体7的远端区域。结果表明，IL4R基因座与造血受体家族的其他成员没有连锁关系。有趣的是，人类染色体16上的位置表明IL4R可能是重排的候选基因，因为12;16易位常与黏液样脂肪肉瘤相关。
