Ashworth A, Williams B P, Buchberg A M, Goodfellow P N, Solomon E, Potter J, Willison K R
Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom.
Genomics. 1989 Apr;4(3):323-7. doi: 10.1016/0888-7543(89)90337-6.
We have determined the mouse and human chromosomal location of a gene (Zfp-3) that codes for a protein that contains potential DNA zinc-binding fingers. An analysis of the segregation of restriction fragment length polymorphisms in recombinant inbred strains and in an interspecific backcross demonstrated that Zfp-3 is located on mouse chromosome 11. Zfp-3 is very closely linked to the Trp53-1 locus but unlinked to another finger protein gene Zfp-4 located on mouse chromosome 8. In humans ZFP3 has been localized to chromosome 17p12-17pter and thus is part of the conserved linkage group between this chromosome and the distal half of mouse chromosome 11.
我们已经确定了一个基因（Zfp-3）在小鼠和人类染色体上的位置，该基因编码一种含有潜在DNA锌结合结构域的蛋白质。通过对重组近交系和种间回交中限制性片段长度多态性分离情况的分析表明，Zfp-3位于小鼠11号染色体上。Zfp-3与Trp53-1位点紧密连锁，但与位于小鼠8号染色体上的另一个锌指蛋白基因Zfp-4不连锁。在人类中，ZFP3定位于17号染色体p12-pter区域，因此是该染色体与小鼠11号染色体远端之间保守连锁群的一部分。
