Stavri Michael, Mathew K T, Gibbons Simon
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Phytochemistry. 2006 Jul;67(14):1530-3. doi: 10.1016/j.phytochem.2006.05.011. Epub 2006 Jun 23.
A study of the chemistry and antibacterial activity of Scrophularia deserti led to the isolation of eight compounds, including the metabolite 3(zeta)-hydroxy-octadeca-4(E),6(Z)-dienoic acid (1). The known compounds ajugoside (2), scropolioside B (3), 6-O-alpha-L-rhamnopyranosylcatalpol (4), buddlejoside A(8) (5), scrospioside A (6), laterioside (7) and 3R-1-octan-3-yl-3-O-beta-D-glucopyranoside (8) were also isolated. Compounds 1-3 exhibited moderate antibacterial activity against strains of multidrug and methicillin-resistant Staphylococcus aureus (MRSA) and a panel of rapidly growing mycobacteria with minimum inhibitory concentration (MIC) values ranging from 32 to 128 microg/ml.
一项对荒漠玄参的化学性质和抗菌活性的研究导致分离出了8种化合物，其中包括代谢物3(Z)-羟基-十八碳-4(E),6(Z)-二烯酸(1)。还分离出了已知化合物筋骨草苷(2)、玄参苷B(3)、6-O-α-L-鼠李吡喃糖基梓醇(4)、醉鱼草苷A(8)(5)、玄参苷A(6)、laterioside(7)和3R-1-辛烷-3-基-3-O-β-D-吡喃葡萄糖苷(8)。化合物1-3对多重耐药和耐甲氧西林金黄色葡萄球菌(MRSA)菌株以及一组快速生长的分枝杆菌表现出中等抗菌活性，其最低抑菌浓度(MIC)值范围为32至128微克/毫升。
