从. 中分离具有 TRAIL 耐药性克服活性的各种类黄酮
Isolation of Various Flavonoids with TRAIL Resistance-Overcoming Activity from .
机构信息
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Plant Molecular Science Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
出版信息
Molecules. 2022 Dec 28;28(1):264. doi: 10.3390/molecules28010264.
Eighteen compounds, including fourteen flavonoids (-), one steroid (), two fatty acids (,), and one nitrogen-containing compound (), were isolated from the methanol extract of the whole plant collected in Thailand. Compounds - and - exhibited tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance-overcoming activity. Among them, bonanzin () and cirsilineol () had particularly strong TRAIL resistance-overcoming activity, where the IC values against the human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL) were 10.7 μM and 5.9 μM, respectively.
从泰国采集的全株植物甲醇提取物中分离得到 18 种化合物，包括 14 种黄酮类化合物（-）、1 种甾体（）、2 种脂肪酸（、）和 1 种含氮化合物（）。化合物 - 和 - 表现出肿瘤坏死因子相关凋亡诱导配体（TRAIL）耐药性克服活性。其中，bonanzin（）和 cirsilineol（）具有特别强的 TRAIL 耐药性克服活性，在 TRAIL（100ng/mL）存在的情况下，对人胃腺癌细胞系 AGS 的 IC 值分别为 10.7μM 和 5.9μM。
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