Iijima Yoshio, Iwamoto Tomotada, Nukuzuma Souichi, Ohishi Hideaki, Hayashi Kozaburo, Kobayashi Nobumichi
Department of Microbiology, Kobe Institute of Health, Minatojima-nakamachi, Kobe 650-0046, Japan.
Scand J Infect Dis. 2006;38(6-7):490-6. doi: 10.1080/00365540500532134.
An outbreak of group A rotavirus infection resulted in gastroenteritis among disabled adults in an isolated rehabilitation institution in Kobe, Japan. Of the 95 residents, 16 were diagnosed with rotavirus illness. The causative agent was a single strain of typical human group A rotavirus belonging to VP7 serotype G2, VP4 genotype P[4], and NSP4 genotype A. Mean duration of stay was significantly longer for residents with rotavirus illness (22.1+/-11.8 years) than for residents without the disease (13.5+/-10.6 years; P=0.01). Age, sex, disability and location of resident rooms displayed no significant relationships with illness. These observations suggest that long-term residence in a closed community, which might be related to absence of immuno-stimulation, represents a risk factor for rotavirus illness.
在日本神户一家与世隔绝的康复机构中，A组轮状病毒感染爆发，导致残疾成年人患上肠胃炎。95名住客中，16人被诊断感染轮状病毒。病原体是一株典型的人类A组轮状病毒，属于VP7血清型G2、VP4基因型P[4]和NSP4基因型A。感染轮状病毒的住客平均住院时间（22.1±11.8年）显著长于未感染该疾病的住客（13.5±10.6年；P=0.01）。住客的年龄、性别、残疾情况及病房位置与疾病无显著关联。这些观察结果表明，在封闭社区长期居住可能与缺乏免疫刺激有关，是轮状病毒疾病的一个风险因素。
