Wang Lu, Liu Simin, Pradhan Aruna D, Manson Joann E, Buring Julie E, Gaziano J Michael, Sesso Howard D
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Am J Epidemiol. 2006 Sep 15;164(6):576-85. doi: 10.1093/aje/kwj240. Epub 2006 Jun 26.
The authors conducted a nested case-control study from 1992 to 2003 among US women aged 45 years or older and free from cardiovascular disease and cancer to examine the prospective association among plasma lycopene, other carotenoids, and the risk of developing type 2 diabetes. During 10 years of follow-up, 470 cases of incident type 2 diabetes were selected and individually matched on age (+/- 1 year) and follow-up time to 470 nondiabetic controls. Baseline plasma levels of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin were similar in cases and controls (all p > 0.05). A possible crude inverse association between plasma lycopene and risk of type 2 diabetes was attenuated upon multivariate adjustment. After control for plasma total cholesterol and known diabetes risk factors, the multivariate odds ratios of type 2 diabetes in the highest versus the lowest quartile of plasma carotenoids were 1.13 (95% confidence interval (CI): 0.60, 2.13) for lycopene, 1.27 (95% CI: 0.63, 2.57) for alpha-carotene, 1.10 (95% CI: 0.57, 2.13) for beta-carotene, 0.91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women.
作者于1992年至2003年在美国45岁及以上且无心血管疾病和癌症的女性中开展了一项巢式病例对照研究，以探讨血浆番茄红素、其他类胡萝卜素与2型糖尿病发病风险之间的前瞻性关联。在10年的随访期间，选取了470例2型糖尿病新发病例，并根据年龄（±1岁）和随访时间与470名非糖尿病对照个体进行匹配。病例组和对照组的血浆番茄红素、α-胡萝卜素、β-胡萝卜素、β-隐黄质和叶黄素/玉米黄质的基线水平相似（所有p>0.05）。血浆番茄红素与2型糖尿病风险之间可能存在的粗略反向关联在多变量调整后减弱。在控制血浆总胆固醇和已知的糖尿病风险因素后，血浆类胡萝卜素最高四分位数与最低四分位数相比，2型糖尿病的多变量比值比分别为：番茄红素1.13（95%置信区间（CI）：0.60，2.13）、α-胡萝卜素1.27（95%CI：0.63，2.57）、β-胡萝卜素1.10（95%CI：0.57，2.13）、β-隐黄质0.91（95%CI：0.46，1.81）、叶黄素/玉米黄质1.35（95%CI：0.68，2.69）。中年及老年女性的基线血浆类胡萝卜素与2型糖尿病风险之间不存在前瞻性关联。
