在治疗期间出现了一株对卡泊芬净敏感性降低的克柔念珠菌分离株。
Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy.
作者信息
Hakki Morgan, Staab Janet F, Marr Kieren A
机构信息
Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98109, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jul;50(7):2522-4. doi: 10.1128/AAC.00148-06.
Abstract
Clinical failure associated with reduced susceptibility to caspofungin has been described in Candida albicans and C. parapsilosis. We report a case of Candida krusei infection that progressed despite caspofungin therapy. Reduced microbial susceptibility to all three echinocandins (caspofungin, anidulafungin, and micafungin) was noted but was not associated with mutations in FKS1.
摘要
白色念珠菌和近平滑念珠菌中已出现与对卡泊芬净敏感性降低相关的临床治疗失败情况。我们报告了1例克鲁斯念珠菌感染病例，尽管接受了卡泊芬净治疗，但感染仍持续进展。研究发现该微生物对所有三种棘白菌素（卡泊芬净、阿尼芬净和米卡芬净）的敏感性均降低，但这与FKS1基因突变无关。
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