Perencevich Molly, Burakoff Robert
Harvard Medical School, Boston, Massachusetts, USA.
Inflamm Bowel Dis. 2006 Jul;12(7):651-64. doi: 10.1097/01.MIB.0000225330.38119.c7.
An increasing amount of evidence suggests that enteric flora may have a role in the pathogenesis of inflammatory bowel disease (IBD). Patients with IBD appear to have an altered composition of luminal bacteria that may provide the stimulus for the chronic inflammation characterizing IBD. The suspected role of bacteria in the pathogenesis of IBD provides the rationale for using agents, such as antibiotics, that alter the intestinal flora. However, there remains much uncertainty about the optimal use of antibiotics in the treatment of Crohn's disease, ulcerative colitis, and pouchitis. This article reviews the literature and presents a clinical model for the use of antibiotics in IBD.
越来越多的证据表明，肠道菌群可能在炎症性肠病（IBD）的发病机制中起作用。IBD患者的管腔细菌组成似乎发生了改变，这可能为IBD特有的慢性炎症提供了刺激。细菌在IBD发病机制中的可疑作用为使用改变肠道菌群的药物（如抗生素）提供了理论依据。然而，在克罗恩病、溃疡性结肠炎和袋炎的治疗中，抗生素的最佳使用仍存在很多不确定性。本文回顾了相关文献，并提出了IBD中使用抗生素的临床模型。
