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氯雷他定和盐酸西替利嗪对组胺诱导的皮肤反应的抑制作用。

Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl.

作者信息

Kontou-Fili K, Paleologos G, Herakleous M

机构信息

Section of Allergy, Laikon General Hospital, Athens, Greece.

出版信息

Eur J Clin Pharmacol. 1989;36(6):617-9. doi: 10.1007/BF00637746.

DOI:10.1007/BF00637746
PMID:2570701
Abstract

The skin reactivity to histamine was measured in 10 healthy and 10 atopic subjects after the ingestion of single doses of loratadine 10 mg, cetirizine diHCl 10 mg and placebo, in a double-blind cross-over randomized study. The anti-H1 effect of cetirizine diHCl proved to be significantly more rapid, more pronounced and longer lasting than that of loratadine.

摘要

在一项双盲交叉随机研究中，对10名健康受试者和10名特应性受试者在服用单剂量10毫克氯雷他定、10毫克二盐酸西替利嗪和安慰剂后，测量其对组胺的皮肤反应性。结果证明，二盐酸西替利嗪的抗H1作用比氯雷他定显著更快、更明显且持续时间更长。

相似文献

1
Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl.氯雷他定和盐酸西替利嗪对组胺诱导的皮肤反应的抑制作用。
Eur J Clin Pharmacol. 1989;36(6):617-9. doi: 10.1007/BF00637746.
2
Compared peripheral H1 inhibiting effects of cetirizine 2 HCl and loratadine.比较西替利嗪二盐酸盐和氯雷他定对周围H1的抑制作用。
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3
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Skin Pharmacol. 1992;5(1):29-33. doi: 10.1159/000211014.
4
A comparison of central and peripheral effects of cetirizine and loratadine.西替利嗪和氯雷他定的中枢及外周作用比较。
J Int Med Res. 1991 Jul-Aug;19(4):289-95. doi: 10.1177/030006059101900401.
5
The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen.
Br J Dermatol. 1991 Oct;125(4):364-7. doi: 10.1111/j.1365-2133.1991.tb14173.x.
6
Effects of loratadine and cetirizine on actual driving and psychometric test performance, and EEG during driving.氯雷他定和西替利嗪对实际驾驶、心理测量测试表现及驾驶时脑电图的影响。
Eur J Clin Pharmacol. 1992;42(4):363-9. doi: 10.1007/BF00280119.
7
Pharmacological modulation by cetirizine and loratadine of antigen and histamine-induced skin weals and flares, and late accumulation of eosinophils.西替利嗪和氯雷他定对抗原及组胺诱导的皮肤风团和潮红，以及嗜酸性粒细胞晚期聚集的药理调节作用。
J Int Med Res. 1990 Sep-Oct;18(5):366-71. doi: 10.1177/030006059001800504.
8
A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects.西替利嗪、特非那定、氯雷他定、阿司咪唑和氯苯那敏与安慰剂的双盲、单剂量、交叉对照比较：对正常受试者24小时内组胺诱发风团和潮红的抑制作用
J Allergy Clin Immunol. 1990 Oct;86(4 Pt 1):540-7.
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Clin Pharmacol Ther. 1987 Sep;42(3):265-72. doi: 10.1038/clpt.1987.145.
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Inhibition of the cutaneous response to histamine by H1-blocking agents. Quantitative evaluation of microvascular changes in the skin after histamine challenge and a comparison of the effects of a single intake of cetirizine and terfenadine.H1 受体阻断剂对皮肤组胺反应的抑制作用。组胺激发后皮肤微血管变化的定量评估以及单次服用西替利嗪和特非那定效果的比较。
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Suppression of histamine-induced wheal response by loratadine (SCH 29851) over 28 days in man.
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Comparative study of the peripheral and central effects of terfenadine and cetirizine 2 HCl.特非那定与盐酸西替利嗪外周及中枢作用的比较研究
Ann Allergy. 1987 Sep;59(3):235-8.
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Inhibitory effect of cetirizine 2HCl on eosinophil migration in vivo.
Clin Allergy. 1987 Jul;17(4):373-9. doi: 10.1111/j.1365-2222.1987.tb02027.x.
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Effect of cetirizine on mast cell-mediator release and cellular traffic during the cutaneous late-phase reaction.西替利嗪对皮肤迟发相反应期间肥大细胞介质释放及细胞迁移的影响。
J Allergy Clin Immunol. 1989 May;83(5):905-12. doi: 10.1016/0091-6749(89)90104-8.