Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel.
Int J Nanomedicine. 2012;7:449-55. doi: 10.2147/IJN.S28424. Epub 2012 Jan 31.
This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.
本文提出了一种基于扩散反射测量的癌症检测新方法。该方法利用金纳米棒（GNRs）的强光吸收，选择性地靶向鳞状细胞头颈部癌细胞，从而实现对癌组织和非癌组织的区分。本文呈现了组织样体模和体内实验结果，证明了扩散反射测量对 GNR 靶向癌组织与正常非癌组织之间吸收差异的高灵敏度。这种非侵入性和非电离的光学检测方法为癌症检测提供了一种高灵敏度、简单且廉价的工具。
