An Suk Kyoon, Lee Eun, Kim Jae-Jin, Namkoong Kee, Kang Jee In, Jeon Jong Hee, Seok Jeong Ho, Choi Sung Hwan
Department of Psychiatry, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, Korea.
Yonsei Med J. 2006 Jun 30;47(3):343-53. doi: 10.3349/ymj.2006.47.3.343.
To explore whether or not patients with schizophrenia display a more profound impairment of negative emotion processing, we assessed the implicit evaluation of positive and negative emotional stimuli. Twenty patients with schizophrenia (9 paranoid, 11 non-paranoid) and 22 normal controls were instructed to classify emotional pictures according to the intrinsic valence if the pictures were black and white. If the stimuli were color-filtered, participants were instructed to press the positive/negative response key according to the extrinsic valence (assigned valence of color). The error rates of the color-filtered stimuli were used as dependent measures. Normal controls made more errors on trials of the positive pictures when the correct response was the negative response key than when the correct response was the positive response key. The reverse was true on trials of the negative pictures. Patients with schizophrenia, especially paranoid schizophrenia, committed more errors in trials of the positive pictures when the correct response key was the negative response key. However, the reverse was not true on trials of the negative pictures. These findings suggest that patients with paranoid schizophrenia might suffer from an impaired ability to evaluate negative emotions and have a loosening of association within their negative emotional networks.
为探究精神分裂症患者在负性情绪加工方面是否存在更严重的损害，我们评估了对正性和负性情绪刺激的内隐评价。20名精神分裂症患者（9名偏执型，11名非偏执型）和22名正常对照被要求，如果图片是黑白的，则根据其内在效价对情绪图片进行分类。如果刺激是经过颜色过滤的，参与者被要求根据外在效价（赋予颜色的效价）按下正性/负性反应键。经过颜色过滤的刺激的错误率被用作因变量指标。当正确反应为负性反应键时，正常对照在正性图片试验中的错误比正确反应为正性反应键时更多。在负性图片试验中则相反。精神分裂症患者，尤其是偏执型精神分裂症患者，当正确反应键为负性反应键时，在正性图片试验中犯的错误更多。然而，在负性图片试验中情况并非相反。这些发现表明，偏执型精神分裂症患者可能存在负性情绪评价能力受损，且其负性情绪网络中的联想出现松散。
