Hao L, Savalani M M, Zhang Y, Tanner K E, Harris R A
Rapid Manufacturing Research Group, Wolfson School of Mechanical and Manufacturing Engineering, Loughborough University, Loughborough, Leicestershire, UK.
Proc Inst Mech Eng H. 2006 May;220(4):521-31. doi: 10.1243/09544119JEIM67.
Selective laser sintering (SLS) has been investigated for the production of bioactive implants and tissue scaffolds using composites of high-density polyethylene (HDPE) reinforced with hydroxyapatite (HA) with the aim of achieving the rapid manufacturing of customized implants. Single-layer and multilayer block specimens made of HA-HDPE composites with 30 and 40 vol % HA were sintered successfully using a CO2 laser sintering system. Laser power and scanning speed had a significant effect on the sintering behaviour. The degree of particle fusion and porosity were influenced by the laser processing parameters, hence control can be attained by varying these parameters. Moreover, the SLS processing allowed exposure of HA particles on the surface of the composites and thereby should provide bioactive products. Pores existed in the SLS-fabricated composite parts and at certain processing parameters a significant fraction of the pores were within the optimal sizes for tissue regeneration. The results indicate that the SLS technique has the potential not only to fabricate HA-HDPE composite products but also to produce appropriate features for their application as bioactive implants and tissue scaffolds.
为了实现定制植入物的快速制造，人们研究了选择性激光烧结（SLS）技术，以使用羟基磷灰石（HA）增强的高密度聚乙烯（HDPE）复合材料来生产生物活性植入物和组织支架。使用二氧化碳激光烧结系统成功烧结了由HA体积分数为30%和40%的HA-HDPE复合材料制成的单层和多层块状试样。激光功率和扫描速度对烧结行为有显著影响。颗粒融合程度和孔隙率受激光加工参数影响，因此可以通过改变这些参数来实现控制。此外，SLS加工使复合材料表面的HA颗粒暴露，从而应能提供生物活性产品。SLS制造的复合部件中存在孔隙，在某些加工参数下，很大一部分孔隙处于组织再生的最佳尺寸范围内。结果表明，SLS技术不仅有潜力制造HA-HDPE复合产品，还能为其作为生物活性植入物和组织支架的应用产生合适的特性。
