Fisher S E, Daniels I R
Pelican Cancer Foundation, North Hampshire Hospital, Basingstoke, Hampshire, UK.
Colorectal Dis. 2006 Sep;8 Suppl 3:40-2. doi: 10.1111/j.1463-1318.2006.01071.x.
The last 20 years have seen enormous strides forward in the treatment of rectal cancer with the development of improved surgical technique, tumour staging, histopathological audit and multidisciplinary team (MDT) management with emphasis on improving survival and reducing local recurrence rates. However, each rectal cancer discussed at the MDT meeting involves an individual patient. The quality of life for each patient must be taken into account when making treatment decisions, which sometimes may not fit with 'standard' treatment guidelines as the individual patient does not have a 'standard' tumour. For one patient with a tumour 5 cm above the anal verge, a low anterior resection may maintain quality of life with no incontinence and preservation of urinary and sexual function. For another with a tumour at the same level, preoperative chemo-radiotherapy may exacerbate mild incontinence and a low resection may result in a 'perineal stoma'. A decision to perform an abdomino-perineal excision (APE) must not be considered a failure of surgical treatment or be seen as a suboptimal centre by having a high APE rate. On the contrary, APE rates should represent sub-specialization and patient selection. Indeed, good function from a permanent stoma may be better than bad function from a poorly functioning coloanal pouch. Having improved tumour staging, surgical technique, oncological treatment and histopathological assessment, quality of life must not be forgotten. Both quality and quantity of life are important to all patients.
在过去20年里,随着手术技术的改进、肿瘤分期、组织病理学审核以及多学科团队(MDT)管理的发展,直肠癌治疗取得了巨大进展,重点是提高生存率和降低局部复发率。然而,MDT会议上讨论的每一例直肠癌都涉及一名个体患者。在做出治疗决策时,必须考虑每位患者的生活质量,有时这可能不符合“标准”治疗指南,因为个体患者不存在“标准”肿瘤。对于一名肿瘤位于肛缘上方5厘米处的患者,低位前切除术可能维持生活质量,不会出现失禁,且能保留泌尿和性功能。而对于另一名肿瘤处于同一水平的患者,术前放化疗可能会加重轻度失禁,低位切除术可能导致“会阴造口”。实施腹会阴联合切除术(APE)的决定不应被视为手术治疗的失败,也不应因APE率高而被视为次优治疗中心。相反,APE率应体现亚专业水平和患者选择。实际上,永久性造口的良好功能可能优于功能不良的结肠肛管吻合袋的不良功能。在肿瘤分期、手术技术、肿瘤治疗和组织病理学评估得到改善的情况下,生活质量绝不能被遗忘。生活质量和数量对所有患者都很重要。