基因扩增：酵母出现新情况。

Gene amplification: yeast takes a turn.

作者信息

Haber James E, Debatisse Michelle

机构信息

Rosenstiel Center and Department of Biology, Brandeis University, Waltham, MA 02254, USA.

出版信息

Cell. 2006 Jun 30;125(7):1237-40. doi: 10.1016/j.cell.2006.06.012.

DOI:10.1016/j.cell.2006.06.012

PMID:16814711

Abstract

The origins of gene amplifications in mammalian cells have been difficult to analyze because of secondary genome rearrangements. Recent studies in budding yeast, including in this issue of Cell, have provided new insights into the role of palindromic sequences in gene amplification.

摘要

由于存在二次基因组重排，哺乳动物细胞中基因扩增的起源一直难以分析。包括本期《细胞》杂志在内，近期对芽殖酵母的研究为回文序列在基因扩增中的作用提供了新见解。