一项评估抗焦虑药物（劳拉西泮、地西泮和安慰剂）治疗神经症的比较临床研究。

A comparative clinical study for the evaluation of antianxiety agents, (lorazepam, diazepam and placebo), in neurosis.

作者信息

Itoh H, Ohtsuka N, Kamishima K, Kaizawa S, Miura S

出版信息

Folia Psychiatr Neurol Jpn. 1977;31(1):25-35. doi: 10.1111/j.1440-1819.1977.tb02680.x.

DOI:10.1111/j.1440-1819.1977.tb02680.x

Abstract

To evaluate the clinical effects of lorazepam on neurosis, a double-blind controlled trial by group comparison procedure was carried out using diazepam and placebo as control drugs. The clinical improvement and aggravation rates by means of a variety of assessment of change were compared between each of the two active drugs and placebo. The superiority, characteristics of therapeutic effects and minor side effects of lorazepam which is similar to those of diazepam, a standard benzodiazepine anxiolytic for the treatment of neurosis, were demonstrated. From this study, many important problems which might be influenced upon the outcome of the pharmacotherapy on neurotics, such as positive and negative placebo effects, aggravation and drop-out during the trial, were also evaluated.

摘要

为评估劳拉西泮对神经症的临床疗效，采用地西泮和安慰剂作为对照药物，通过组间比较程序进行了一项双盲对照试验。比较了两种活性药物与安慰剂各自通过多种变化评估方法得出的临床改善率和加重率。结果证明了劳拉西泮与治疗神经症的标准苯二氮䓬类抗焦虑药地西泮具有相似的优势、治疗效果特点及轻微副作用。通过本研究，还评估了许多可能影响神经症药物治疗结果的重要问题，如阳性和阴性安慰剂效应、试验期间的病情加重及退出情况。