Rickels K, Case W G, Chung H R, Morris R J, Pereira-Ogan J, Rosenfeld H, Segal A
Int Pharmacopsychiatry. 1976;11(2):93-101. doi: 10.1159/000468217.
The response of 134 anxious neurotic outpatients to lorazepam, diazepam, and placebo was assessed in a 4-week double-blind trial. Both active drugs produced significantly more symptom reduction than placebo. Lorazepam, however, proved effective primarily in those patients who did not complain of sedation, and produced greatest improvement in initially sicker patients. Sedation was significantly more disturbing to lorazepam-treated patients than to diazepam-treated patients. Present findings suggested that 3 mg/day of lorazepam may be too high a dosage for mildly anxious patients, while 15 mg/day of diazepam seems an appropriate dosage for mildly anxious patients but may be too low a dosage for highly anxious patients.
在一项为期4周的双盲试验中，评估了134名焦虑性神经症门诊患者对劳拉西泮、地西泮和安慰剂的反应。两种活性药物产生的症状减轻均显著多于安慰剂。然而，劳拉西泮主要对那些未抱怨有镇静作用的患者有效，并且在最初病情较重的患者中产生了最大程度的改善。与地西泮治疗的患者相比，镇静作用对劳拉西泮治疗的患者造成的困扰明显更大。目前的研究结果表明，对于轻度焦虑患者，每天3毫克的劳拉西泮剂量可能过高，而对于轻度焦虑患者，每天15毫克的地西泮似乎是合适的剂量，但对于高度焦虑患者可能剂量过低。
