Yordanov M, Golkocheva E, Najdenski H
Department of Immunology, Institute of Microbiology, Sofia, Bulgaria.
Folia Microbiol (Praha). 2006;51(1):27-32. doi: 10.1007/BF02931446.
The ability of released proteins (Yops) and surface lipopolysaccharides (LPS) from the wild-type strain Yersinia enterocolitica 8081-L2, serotype 0:8 to influence the complement activity was determined. Yops and LPS from wild-type and mutant strains showed different ability to affect the classical pathway (CP) functional complement activity in vitro. The serum CP activity was inhibited during the infection induced with six Y. enterocolitica and three Y. pseudotuberculosis strains in rabbits. The changed complement activity might be of importance for the course of Yersinia infections.
测定了野生型小肠结肠炎耶尔森菌8081-L2（血清型0:8）释放的蛋白质（Yops）和表面脂多糖（LPS）影响补体活性的能力。野生型和突变株的Yops和LPS在体外影响经典途径（CP）功能性补体活性的能力不同。用六种小肠结肠炎耶尔森菌和三种假结核耶尔森菌菌株感染兔子时，血清CP活性受到抑制。补体活性的改变可能对耶尔森菌感染的病程具有重要意义。
