Chien Chih-Yen, Su Chih-Ying, Hwang Chung-Feng, Chuang Hui-Ching, Chen Ching-Mei, Huang Chao-Cheng
Department of Otolaryngology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
J Surg Oncol. 2006 Oct 1;94(5):413-7. doi: 10.1002/jso.20546.
Although elective neck dissection has become a popular treatment modality for early oral cancer among most head and neck surgeons, a large portion of patients revealed pathological N0 postoperatively. Our study is aimed to evaluate the expressions of the angiogenic factors, vascular endothelial growth factor (VEGF), and CD105 (endoglin) on the prediction of neck metastasis for clinical N0 patients in early oral cancer.
Between July 1996 and July 2005, the preoperative biopsy specimens among 176 patients who underwent surgical treatment for early oral cancer were retrieved for the immunohistochemical study for VEGF and CD105.
High expressions of CD105 and VEGF significantly correlated with positive nodal metastasis, respectively (P<0.001). The expression of CD105 also significantly correlated with that of VEGF (P<0.001). Furthermore, the sensitivity and specificity for prediction of cervical metastasis by high expressions of CD105 versus VEGF were 81.8% and 97.7% versus 93.2% and 72%, respectively. Low expression of CD105 and VEGF also significantly correlated with higher survival rate, respectively (P<0.001).
Besides the image studies, the expressions of both CD105 and VEGF could be useful to guide the elective treatment for clinical N0 neck in early oral cancer.
尽管选择性颈部清扫术已成为大多数头颈外科医生治疗早期口腔癌的常用方法，但很大一部分患者术后病理检查显示为N0。我们的研究旨在评估血管生成因子、血管内皮生长因子（VEGF）和CD105（内皮糖蛋白）的表达对早期口腔癌临床N0患者颈部转移的预测价值。
1996年7月至2005年7月期间，收集了176例接受早期口腔癌手术治疗患者的术前活检标本，进行VEGF和CD105的免疫组织化学研究。
CD105和VEGF的高表达分别与阳性淋巴结转移显著相关（P<0.001）。CD105的表达也与VEGF的表达显著相关（P<0.001）。此外，CD105高表达与VEGF高表达预测颈部转移的敏感性和特异性分别为81.8%和97.7%以及93.2%和72%。CD105和VEGF的低表达也分别与较高的生存率显著相关（P<0.001）。
除影像学检查外，CD105和VEGF的表达有助于指导早期口腔癌临床N0颈部的选择性治疗。
