Horn F K, Link B, Dehne K, Lämmer R, Jünemann A G
Augenklinik mit Poliklinik, Friedrich-Alexander Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen.
Ophthalmologe. 2006 Oct;103(10):866-72. doi: 10.1007/s00347-006-1389-5.
Flicker light is an easy method to test sensory function after stress. The aim of this study was to determine the influence of flicker stress on temporal contrast sensitivity in healthy controls and patients with glaucomatous alteration of the optic disk.
A commercially available full-field stimulator (Retiport, Roland Consult) equipped with white LEDs was modified to perform psychophysical tests. The patients underwent measurements of the recovery time interval from cessation of flicker stress until recognition of a pregiven flicker contrast after photo stress. In addition, we studied contrast sensitivity with a continuous flickering target and with a flicker burst protocol avoiding adaptation to prevailing flicker. All tests were performed at a constant retinal illumination and at a frequency of 37 Hz for provocation as well as for contrast sensitivity tests.
Normal healthy controls (40), "preperimetric" (62), and "perimetric" (52) open-angle glaucoma patients were studied. Exclusion criteria were age lower than 31 years, visual acuity under 0.6, and perimetric mean defect more than 9.5 dB.
Recovery time after flicker stress was significantly longer in patients than in normals and longer in perimetric than in preperimetric patients. Analysis in perimetric patients revealed a larger area under ROC for the provocation test (0.95) than in contrast sensitivity tests (continuous flicker method: 0.90, flicker burst mode: 0.84).
High-power LEDs which are installed in modern full-field devices can be used as a helpful tool to study psychophysical properties. In the present study it could be shown that threshold, adaptation, and recovery of temporal transfer characteristics are impaired in many patients with glaucoma.
闪烁光是应激后测试感觉功能的一种简便方法。本研究的目的是确定闪烁应激对健康对照者和视盘有青光眼性改变患者的时间对比敏感度的影响。
对配备白色发光二极管的市售全视野刺激器（Retiport，罗兰咨询公司）进行改装，以进行心理物理学测试。患者接受从闪烁应激停止到光应激后识别给定闪烁对比度的恢复时间间隔测量。此外，我们研究了连续闪烁目标和避免适应主导闪烁的闪烁脉冲协议下的对比敏感度。所有测试均在恒定视网膜照度下，以37Hz的频率进行刺激以及对比敏感度测试。
研究了正常健康对照者（40例）、“视野检查前”（62例）和“视野检查”（52例）开角型青光眼患者。排除标准为年龄低于31岁、视力低于0.6以及视野平均缺损超过9.5dB。
患者闪烁应激后的恢复时间明显长于正常对照者，视野检查患者的恢复时间长于视野检查前患者。对视野检查患者的分析显示，激发试验的ROC曲线下面积（0.95）大于对比敏感度测试（连续闪烁法：0.90，闪烁脉冲模式：0.84）。
安装在现代全视野设备中的高功率发光二极管可作为研究心理物理学特性的有用工具。在本研究中可以表明，许多青光眼患者的时间传递特性的阈值、适应性和恢复受损。
