DFG-Klinische Forschergruppe Glaukome, Department of Ophthalmology, University of Eriangen-Nürnberg, Erlangen *Department of Medical Statistics and Documentation, University of Eriangen-Nürnberg, Erlangen, Germany.
J Glaucoma. 1994 Fall;3(3):206-13.
The value of a full-field flicker stimulus in glaucoma diagnosis was tested. In 69 normals, 60 ocular hypertension, and 50 manifest primary openangle glaucoma patients, the temporal contrast (flicker) thresholds were tested with a sinusoidally flickering white light of constant mean photopic luminance (10 candela/m) presented in a full-field bowl. A modulatable xenon-arc lamp was used, and only one frequency (37.1 Hz) was tested. Luminances were corrected according to pupil widths. No significant age relationships of flicker thresholds were found in normal eyes. Forty (80%) of glaucoma eyes were recognized as pathologic at a specificity of 93%. In the glaucoma group, significant correlations of flicker thresholds were found with measurements of neuroretinal rim areas of the optic disc (linear r = -0.61, nonparametric r = -0.59, p = 0.001) and with perimetric mean defects (linear r = 0.74, nonparametric r = 0.66, p = 0.0001). Because of its high sensitivity and the significant correlation with perimetric losses and neuroretinal rim areas, the full-field flicker test can be used as a quick (5 min per eye) additional examination in the diagnosis of glaucoma.
研究了全场闪烁刺激在青光眼诊断中的价值。在 69 名正常人、60 名高眼压症患者和 50 名原发性开角青光眼患者中，使用恒明视觉亮度（10 坎德拉/米）的正弦闪烁白光，在全场碗中测试了颞部对比度（闪烁）阈值。使用可调节氙弧灯，仅测试了一个频率（37.1 Hz）。亮度根据瞳孔宽度进行校正。在正常眼中，未发现闪烁阈值与年龄有显著关系。40 只（80%）青光眼眼被识别为病理性，特异性为 93%。在青光眼组中，闪烁阈值与视神经盘神经视网膜边缘区域的测量值（线性 r = -0.61，非参数 r = -0.59，p = 0.001）和周边平均缺损（线性 r = 0.74，非参数 r = 0.66，p = 0.0001）呈显著相关。由于其灵敏度高，与周边损失和神经视网膜边缘区域有显著相关性，全场闪烁测试可作为青光眼诊断的快速（每只眼 5 分钟）附加检查。
