Merrick J, Merrick E, Morad M, Kandel I
National Institute of Child Health and Human Development, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Minerva Pediatr. 2006 Jun;58(3):211-8.
Ancient scripture and paintings together with several medical reports on the effect of alcohol on the newborn over the past 300 years finally led to the description of the fetal alcohol syndrome in the 1970s by French and American research groups. Maternal alcohol abuse during pregnancy can result in the specific pattern of malformations and neurocognitive deficits characteristic of this syndrome. Diagnostic criteria and classifications have been developed and in the 1990s reports showed the long-term consequences for these children. In recent years several studies from different countries have shown that prenatal alcohol exposure will lead to life-long consequences on physical development, intellectual development, behavior, social development, occupation, independence, sexuality or sexual behavior and increased risk of suicidality. In this review of long-term observation studies we found that the prenatal exposure to alcohol have permanent and life-long damage, which impair both the social and occupational future of the person exposed with a need for life-long assistance in order for that person to function at an optimal level. Primary prevention and early intervention with general public health educational efforts seems to be the best way forward.
古代经文和绘画作品,以及过去300年间关于酒精对新生儿影响的若干医学报告,最终促使法美研究团队在20世纪70年代描述了胎儿酒精综合征。孕期母亲酗酒会导致该综合征特有的畸形模式和神经认知缺陷。诊断标准和分类已经制定出来,20世纪90年代的报告显示了这些儿童的长期后果。近年来,来自不同国家的多项研究表明,产前酒精暴露会对身体发育、智力发育、行为、社会发展、职业、独立性、性取向或性行为产生终身影响,并增加自杀风险。在这项对长期观察研究的综述中,我们发现产前酒精暴露会造成永久性的终身损害,这会损害受暴露者的社会和职业前景,需要终身帮助才能使其达到最佳功能水平。通过开展公众健康教育进行一级预防和早期干预似乎是最佳的前进方向。