Müller G, Schempp W
Institut für Humangenetik und Anthropologie der Universität, Freiburg, Federal Republic of Germany.
Hum Genet. 1991 Nov;88(1):59-63. doi: 10.1007/BF00204930.
Within our project of comparative mapping of candidate genes for sex-determination/testis differentiation, we used a cloned probe from the human ZFY locus for comparative hybridization studies in hominoids. As in the human, the ZFY probe detects X- and Y-specific restriction fragments in the chimpanzee, the gorilla, the orangutan, and the gibbon. Furthermore, the X-specific hybridization site in the great apes resides in Xp21.3, the same locus defining ZFX in the human. The Y-specific locus of ZFY maps closely to the early replicating pseudoautosomal segment in the telomeric or subtelomeric position of the Y chromosomes of the great apes, again as found in the human. Thus, despite cytogenetically visible structural alterations within the euchromatic parts of the Y chromosomes of the human species and the great apes, a segment of the Y chromosome defined by the pseudoautosomal region and ZFY seems to be more strongly conserved than the rest of the Y chromosome.
在我们关于性别决定/睾丸分化候选基因的比较图谱绘制项目中，我们使用了来自人类ZFY基因座的克隆探针，在类人猿中进行比较杂交研究。与人类一样，ZFY探针在黑猩猩、大猩猩、猩猩和长臂猿中检测到X和Y特异性限制性片段。此外，大型猿类中X特异性杂交位点位于Xp21.3，这与人类中定义ZFX的基因座相同。ZFY的Y特异性基因座紧密映射到大猿Y染色体端粒或亚端粒位置的早期复制假常染色体区段，这在人类中也有发现。因此，尽管人类和大型猿类的Y染色体常染色质部分在细胞遗传学上可见结构改变，但由假常染色体区域和ZFY定义的Y染色体区段似乎比Y染色体的其余部分更具保守性。
