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2-脱氧-D-葡萄糖对疱疹病毒诱导的细胞DNA合成抑制作用的影响。

Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis.

作者信息

Ludwig H, Rott R

出版信息

J Virol. 1975 Aug;16(2):217-21. doi: 10.1128/JVI.16.2.217-221.1975.

DOI:10.1128/JVI.16.2.217-221.1975
PMID:168399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC354657/
Abstract

In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.

摘要

在伪狂犬病病毒感染的细胞中，宿主DNA合成在感染后4至5小时关闭。然而，在存在0.5 mM 2-脱氧-D-葡萄糖的情况下，细胞和病毒DNA的合成在整个病毒复制周期中均不受影响地进行。在2-脱氧-D-葡萄糖存在下，放射性胸苷进入模拟感染细胞的摄取未发生改变。病毒特异性蛋白质合成和颗粒形成也在含有脱氧糖的培养基中进行，但产生的病毒颗粒无感染性且细胞融合受到抑制。

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本文引用的文献

1
MECHANISM OF INHIBITION OF CELLULAR DNA SYNTHESIS BY PSEUDORABIES VIRUS.伪狂犬病病毒抑制细胞DNA合成的机制
Virology. 1965 Jan;25:22-9. doi: 10.1016/0042-6822(65)90247-3.
2
THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.单纯疱疹病毒的增殖。II. 感染的HEP - 2细胞中蛋白质合成与病毒DNA复制之间的关系。
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Kinetics of cellular and viral DNA synthesis in equine abortion (herpes) virus infection of L-M cells.马流产（疱疹）病毒感染L-M细胞时细胞和病毒DNA合成的动力学
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Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose.伴刀豆球蛋白A、抗血清和2-脱氧-D-葡萄糖对疱疹病毒诱导的细胞融合的抑制作用。
J Virol. 1974 Aug;14(2):307-14. doi: 10.1128/JVI.14.2.307-314.1974.
5
Effect of 2-deoxy-D-glucose on the multiplication of Semliki Forest virus and the reversal of the block by mannose.2-脱氧-D-葡萄糖对塞姆利基森林病毒增殖的影响以及甘露糖对该阻断作用的逆转
Virology. 1973 Jul;54(1):179-89. doi: 10.1016/0042-6822(73)90127-x.
6
Inhibition of glycoprotein biosynthesis of influenza virus by D-glucosamine and 2-deoxy-D-glucose.D-葡萄糖胺和2-脱氧-D-葡萄糖对流感病毒糖蛋白生物合成的抑制作用。
Virology. 1972 Sep;49(3):723-34. doi: 10.1016/0042-6822(72)90529-6.
7
Nucleoside-diphosphate derivatives of 2-deoxy-D-glucose in animal cells.动物细胞中2-脱氧-D-葡萄糖的核苷二磷酸衍生物
Eur J Biochem. 1974 Nov 1;49(1):237-47. doi: 10.1111/j.1432-1033.1974.tb03828.x.
8
Inhibition of glycosylation of the influenza virus hemagglutinin.流感病毒血凝素糖基化的抑制作用。
J Virol. 1974 Nov;14(5):1023-34. doi: 10.1128/JVI.14.5.1023-1034.1974.
9
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.疱疹病毒大分子合成的调控。I. 三组病毒蛋白合成的级联调控。
J Virol. 1974 Jul;14(1):8-19. doi: 10.1128/JVI.14.1.8-19.1974.
10
Effect of 2-deoxy-D-glucose on cell fusion induced by Newcastle disease and herpes simplex viruses.2-脱氧-D-葡萄糖对新城疫病毒和单纯疱疹病毒诱导的细胞融合的影响。
Virology. 1973 Sep;55(1):193-201. doi: 10.1016/s0042-6822(73)81021-9.