2-脱氧-D-葡萄糖对疱疹病毒诱导的细胞DNA合成抑制作用的影响。
Effect of 2-deoxy-D-glucose on herpesvirus-induced inhibition of cellular DNA synthesis.
作者信息
Ludwig H, Rott R
出版信息
J Virol. 1975 Aug;16(2):217-21. doi: 10.1128/JVI.16.2.217-221.1975.
Abstract
In pseudorabies virus-infected cells host DNA synthesis is turned off 4 to 5 h postinfection. In the presence of 0.5 mM 2-deoxy-D-glucose, however, synthesis of both cellular and viral DNA proceeds unimpaired throughout the virus replication cycle. The uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-D-glucose. Virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produced are noninfectious and cell fusion is inhibited.
摘要
在伪狂犬病病毒感染的细胞中，宿主DNA合成在感染后4至5小时关闭。然而，在存在0.5 mM 2-脱氧-D-葡萄糖的情况下，细胞和病毒DNA的合成在整个病毒复制周期中均不受影响地进行。在2-脱氧-D-葡萄糖存在下，放射性胸苷进入模拟感染细胞的摄取未发生改变。病毒特异性蛋白质合成和颗粒形成也在含有脱氧糖的培养基中进行，但产生的病毒颗粒无感染性且细胞融合受到抑制。
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