Kaiser C J, Radsak K
Arch Virol. 1987;94(3-4):229-45. doi: 10.1007/BF01310716.
Monensin, at concentrations which depended on the multiplicity of infection, was found to prevent DNA replication of human cytomegalovirus (HCMV) as well as production of viral progeny in human foreskin fibroblasts. The drug did not affect DNA replication of herpes simplex virus. Inhibition of consecutive HCMV DNA synthesis was also observed following delayed addition of the drug within 12-24 hours postinfection, but was fully reversible upon its removal. Viral replication proceeded, however, without impairment in cultures treated with monensin prior to infection. Induction of viral DNA polymerase activity was not impeded by the inhibitor. Analysis of protein- and glycoprotein synthesis revealed that monensin interfered with the production of a number of HCMV-specific polypeptides. Furthermore, evidence was obtained that the drug may hinder intracellular transport of a 135 kd glycopolypeptide.
莫能菌素在取决于感染复数的浓度下，被发现可阻止人巨细胞病毒（HCMV）的DNA复制以及人包皮成纤维细胞中病毒子代的产生。该药物不影响单纯疱疹病毒的DNA复制。在感染后12 - 24小时内延迟添加该药物后，也观察到连续的HCMV DNA合成受到抑制，但去除药物后这种抑制完全可逆。然而，在感染前用莫能菌素处理的培养物中，病毒复制没有受到损害。该抑制剂并未阻碍病毒DNA聚合酶活性的诱导。蛋白质和糖蛋白合成分析表明，莫能菌素干扰了多种HCMV特异性多肽的产生。此外，有证据表明该药物可能会阻碍一种135 kd糖多肽的细胞内运输。
