伴刀豆球蛋白A、抗血清和2-脱氧-D-葡萄糖对疱疹病毒诱导的细胞融合的抑制作用。
Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose.
作者信息
Ludwig H, Becht H, Rott R
出版信息
J Virol. 1974 Aug;14(2):307-14. doi: 10.1128/JVI.14.2.307-314.1974.
Abstract
Pseudorabies virus-induced cell fusion in rabbit kidney cells can be prevented by Concanavalin A added early after infection. The infected cells are not agglutinated and the infectivity of cell-free virus is not reduced. Sera from productively infected animals also inhibit polykaryocytosis, whereas a hyperimmune serum directed against virus structural components has no effect. 2-Deoxy-d-glucose reversibly disturbs virus-induced fusion and reduces significantly the virus infectivity.
摘要
感染后早期添加伴刀豆球蛋白A可预防伪狂犬病病毒诱导的兔肾细胞融合。受感染的细胞不会发生凝集，且无细胞病毒的感染性也不会降低。有病毒增殖性感染的动物血清也能抑制多核细胞形成，而针对病毒结构成分的超免疫血清则无此作用。2-脱氧-D-葡萄糖可可逆地干扰病毒诱导的融合，并显著降低病毒感染性。
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