氟代糖抑制不同包膜病毒的生物学特性。
Fluorosugars inhibit biological properties of different enveloped viruses.
作者信息
Schmidt M F, Schwarz R T, Ludwig H
出版信息
J Virol. 1976 Jun;18(3):819-23. doi: 10.1128/JVI.18.3.819-823.1976.
Abstract
Both 2-deoxy-2-fluoro-D-glucose and 2-deoxy-2-fluoro-D-mannose were found to be potent inhibitors of the synthesis of infectious Semliki forest and fowl plague virus in chicken embryo cells and also of pseudorabies virus grown in rabbit kidney cells. It was found that the pseudorabies virus-mediated cell fusion and the synthesis of functional hemagglutinin of fowl plague virus were blocked. In all cases the 2-deoxy-2-fluoro-D-mannose-caused inhibition was stronger than the 2-deoxy-2-fluoro-D-glucose- or 2-deoxy-D-glucose-mediated blocks. Studies on the virus-specified proteins from Semiliki forest virus-infected cells grown in the presence of the inhibitors show that the target of the fluorosugar action, parallel to the well-studied effects of 2-deoxy-D-glucose, is the glycoprotein biosynthesis.
摘要
2-脱氧-2-氟-D-葡萄糖和2-脱氧-2-氟-D-甘露糖均被发现是鸡胚细胞中传染性塞姆利基森林病毒和禽痘病毒合成的有效抑制剂，也是兔肾细胞中生长的伪狂犬病病毒合成的有效抑制剂。研究发现，伪狂犬病病毒介导的细胞融合以及禽痘病毒功能性血凝素的合成均被阻断。在所有情况下，2-脱氧-2-氟-D-甘露糖引起的抑制作用都比2-脱氧-2-氟-D-葡萄糖或2-脱氧-D-葡萄糖介导的阻断作用更强。对在抑制剂存在下生长的受塞姆利基森林病毒感染细胞的病毒特异性蛋白质的研究表明，与2-脱氧-D-葡萄糖的充分研究效果相似，氟糖作用的靶点是糖蛋白生物合成。
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