10名烧伤患者的硒流失情况。

Selenium losses in 10 burned patients.

作者信息

Berger M M, Cavadini C, Bart A, Blondel A, Bartholdi I, Vandervale A, Krupp S, Chiolero R, Freeman J, Dirren H

机构信息

Anesthesiology, Centre Hospitalier Universitaire Vaudios (CHUV), CH-1011 Lausanne, Switzerland.

出版信息

Clin Nutr. 1992 Apr;11(2):75-82. doi: 10.1016/0261-5614(92)90014-h.

DOI:10.1016/0261-5614(92)90014-h

PMID:16839976

Abstract

To determine the selenium (Se) losses and balances, 10 patients with burns of 32 +/- 9% (mean +/- SD) of total body surface and aged 36 +/- 9 years were studied from D1 (first post-injury) unitl D7. Cutaneous losses were extracted from the textiles surrounding the patients. Serum and urine were collected until D20. Exudative losses of nitrogen decreased progressively (mean 8.7 +/- 3.8 g/24H). Se was detectable in wound seepage only during excision-grafting: mean operative loss was 342 +/- 191 mug. Mean urinary Se excretion was 41 +/- 13 mug/24H. Operative cutaneous losses led to some negative balances. Serum Se and glutathione peroxydase (GSHPx) were depressed until D20. Serum Se was related to N intake (p < 0.001). The decreased Se and GSHPx levels reflect a deficiency state, which measured losses did not explain, but limitations of the measurement methods prevented detection of Se cutaneous losses 100 mug/24H.

摘要

为确定硒（Se）的损失和平衡情况，对10例烧伤患者进行了研究，这些患者的烧伤面积为全身表面积的32±9%（均值±标准差），年龄为36±9岁，研究时间从伤后第1天（D1）至第7天（D7）。从患者周围的织物中提取皮肤损失量。收集血清和尿液直至第20天（D20）。氮的渗出性损失逐渐减少（平均8.7±3.8g/24小时）。仅在切痂植皮期间伤口渗液中可检测到硒：平均手术损失为342±191μg。平均尿硒排泄量为41±13μg/24小时。手术导致的皮肤损失造成了一些负平衡。血清硒和谷胱甘肽过氧化物酶（GSHPx）在第20天之前一直处于降低水平。血清硒与氮摄入量相关（p<0.001）。硒和GSHPx水平的降低反映了一种缺乏状态，实测损失无法解释这种状态，但测量方法的局限性使得无法检测到每24小时100μg的皮肤硒损失。