Berger M M, Chioléro R
Anesthésiologic, Soins Intensifs de Chirurgie et Centre des Brûlés, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
Burns. 1995 Nov;21(7):507-12. doi: 10.1016/0305-4179(95)00031-6.
Copper, zinc and selenium are involved in free radical scavenging. As trace element status is altered after major burns, related free radical scavenging may be decreased: consequently lipid peroxidation, reflected by increased urinary malondialdehyde excretion (MDA), is considerably increased. This preliminary study aimed to investigate the relationship between trace elements and MDA excretion. Sixteen patients aged 34 +/- 9 years (mean +/- s.d.) burned over 37 +/- 11 per cent of body surface, were studied prospectively. Trace element balance studies from days 1 to 7 and serum and urine concentrations on days 10, 15, 20 and 25 were measured. The first 11 patients (groups 1--SBU < 80, and 2--SBU > or = 80) were given standard supplements and the five next patients increased supplements (group 3, SBU > or = 80). The MDA excretion from days 1 to 3 was correlated with burn severity (r = 0.59). The correlations between serum trace element levels after day 3 and MDA were negative: Cu, r = -0.065; Zn, r = -0.52; Se, r = -0.53. In Group 3, MDA excretion after day 3 decreased with increasing cumulative Zn (r = -0.46) and Se intakes (r = -0.57). It can be concluded that the MDA decrease after day 3 was not clearly attributable to the trace element supplements, but the negative trend observed between Zn and Se supplements and decreased MDA excretion requires further studies.
铜、锌和硒参与自由基清除。由于严重烧伤后微量元素状况会发生改变，相关的自由基清除能力可能会下降：因此，以尿中丙二醛排泄量（MDA）增加为指标的脂质过氧化作用会显著增强。这项初步研究旨在探讨微量元素与MDA排泄之间的关系。对16名年龄在34±9岁（均值±标准差）、烧伤面积达37±11%体表的患者进行了前瞻性研究。测定了第1至7天的微量元素平衡研究以及第10、15、20和25天的血清和尿液浓度。前11名患者（第1组——烧伤指数＜80，以及第2组——烧伤指数≥80）给予标准补充剂，接下来的5名患者增加补充剂（第3组，烧伤指数≥80）。第1至3天的MDA排泄与烧伤严重程度相关（r = 0.59）。第3天后血清微量元素水平与MDA之间的相关性为负：铜，r = -0.065；锌，r = -0.52；硒，r = -0.53。在第3组中，第3天后MDA排泄量随着累积锌摄入量（r = -0.46）和硒摄入量（r = -0.57）的增加而减少。可以得出结论，第3天后MDA的降低并非明显归因于微量元素补充剂，但锌和硒补充剂与MDA排泄量降低之间观察到的负相关趋势需要进一步研究。
