Patat A, Klein M J, Surjus A, Hucher M, Granier J
Biostatistics Department, Roussel UCLAF Romainville, France.
Eur J Clin Pharmacol. 1991;41(3):225-31. doi: 10.1007/BF00315434.
The potential antagonism of a single oral dose of RU 41,656 10 mg on the memory and attention disturbances induced by scopolamine 0.6 mg s.c. have been investigated in a 3 period, placebo controlled, double blind, cross over study in 12 healthy, young volunteers. The effects of the compounds were evaluated by objective tests (Buschke selective reminding test, CFF, simple reaction time, tapping, arithmetical calculation) and subjective measurements (visual analogue scale, side effects questionnaire). Measurements were taken before treatment and 2, 4 and 7 h after RU 41,656. Scopolamine caused anterograde amnesia and sedative effects as which were not counteracted by RU 41,656.
在一项为期3个阶段、安慰剂对照、双盲、交叉研究中，对12名健康年轻志愿者进行了研究，以探讨单次口服10毫克RU 41,656对皮下注射0.6毫克东莨菪碱所致记忆和注意力障碍的潜在拮抗作用。通过客观测试（Buschke选择性提醒测试、临界闪光融合频率、简单反应时间、敲击、算术计算）和主观测量（视觉模拟量表、副作用问卷）对化合物的效果进行评估。在治疗前以及服用RU 41,656后2、4和7小时进行测量。东莨菪碱引起了顺行性遗忘和镇静作用，而RU 41,656并未抵消这些作用。
