Sannita W G, Maggi L, Rosadini G
Center for Neuropsychoactive Drugs, University of Genoa, Italy.
Neuropsychobiology. 1987;17(4):199-205. doi: 10.1159/000118365.
There has been clinical and experimental evidence that cholinergic compounds and precursors of choline are potentially useful in the treatment of dementia. Anticholinergic compounds have also been proposed as a possible acute model for pharmaco-EEG studies focussed on CNS aging. Single doses of scopolamine (0.25-0.75 mg i.m.) and a matching placebo were administered to 8 young healthy volunteers. Quantitative EEG recordings and neuropsychological testing were performed in baseline conditions prior to and 30, 90 and 120 min after drug administration. Scopolamine induced a dose-related increase of relative power in low- and high-frequency components and a decrease in the range 8.0-13.5 Hz and in total signal power. These modifications were found to be limited to the posterior scalp electrode derivations and were observed from the 90-min control onwards. Concomitantly, there was a significant impairment in the subjects' response to neuropsychological testing after the administration of 0.50 and 0.75 mg of scopolamine. At a dose of 0.75 mg, volunteers complained about subjective symptoms which were definitely unpleasant. The effects of this dose on the EEG and the neuropsychological status did not differ significantly from those observed after a dose of 0.50 mg. As regards dose and tolerance, 0.50 mg of scopolamine administered intramuscularly appears to be a suitable dose for pharmaco-EEG studies.
已有临床和实验证据表明，胆碱能化合物和胆碱前体在治疗痴呆方面可能具有潜在作用。抗胆碱能化合物也被提议作为专注于中枢神经系统衰老的药物脑电图研究的一种可能的急性模型。向8名年轻健康志愿者单次肌肉注射东莨菪碱（0.25 - 0.75毫克）和匹配的安慰剂。在给药前的基线条件下以及给药后30、90和120分钟进行定量脑电图记录和神经心理学测试。东莨菪碱导致低频和高频成分的相对功率呈剂量相关增加，8.0 - 13.5赫兹范围内以及总信号功率降低。这些改变仅限于头皮后部电极导联，并且从90分钟对照组开始观察到。同时，在给予0.50毫克和0.75毫克东莨菪碱后，受试者对神经心理学测试的反应出现显著损害。在0.75毫克剂量时，志愿者抱怨有明显不适的主观症状。该剂量对脑电图和神经心理状态的影响与0.50毫克剂量后观察到的影响没有显著差异。就剂量和耐受性而言，肌肉注射0.50毫克东莨菪碱似乎是药物脑电图研究的合适剂量。
