Mosley J W
JAMA. 1975 Sep 1;233(9):967-9.
Two episodes of acute viral hepatitis occurred in each of 34 patients. One episode in each patient was serologically diagnosable as type B hepatitis on the basis of tests for hepatitis B surface antigen or antibody. The other episode was classified as "non-B" on the basis of seronegativity, reinforced by seropositivity in an alternate bout. An epidemiologic background appropriate to "serum" hepatitis, either transfusion (one bout) or illicit self-injection (46 bouts), was associated just as frequently with serologically non-B episodes as with identified type B disease. The diagnosis of type B hepatitis, therefore, should be made only on the basis of serologic tests specific for hepatitis B virus infection. Other cases of sporadic diseases in adults must be labeled "viral hepatitis, type unspecifiable."
34名患者每人都发生了两起急性病毒性肝炎发作。根据乙型肝炎表面抗原或抗体检测，每名患者的一次发作在血清学上可诊断为乙型肝炎。另一次发作根据血清阴性分类为“非乙型”，在另一次发作中血清阳性则进一步证实了这一分类。与“血清”型肝炎相符的流行病学背景，无论是输血（一次发作）还是非法自我注射（46次发作），与血清学上非乙型发作的关联频率与已确诊的乙型疾病相同。因此，乙型肝炎的诊断应仅基于针对乙型肝炎病毒感染的血清学检测。成人中其他散发性疾病病例必须标记为“无法明确类型的病毒性肝炎”。
