Dienstag J L, Alaama A, Mosley J W, Redeker A G, Purcell R H
Ann Intern Med. 1977 Jul;87(1):1-6. doi: 10.7326/0003-4819-87-1-1.
We studied serologically 45 adults who had sporadic acute viral hepatitis that was hepatitis B surface antigen (HBsAg) negative. Two cases were due to hepatitis B virus, as demonstrated by the appearance of antibody to hepatitis B core antigen. In three other patients, the serologic pattern was inconclusive. Of 40 non-B cases, 20 were type A hepatitis and 20 were non-A, non-B hepatitis. Clinically, type A and non-A, non-B hepatitis were indistinguishable; one case of fulminant disease occurred in each group. The type A cases were more frequent in young adults; non-A, non-B disease predominated in women 35 years or older. Epidemiologic backgrounds were generally similar, including illicit self-injection; but four transfusion-associated cases were limited to the non-A, non-B group. We conclude that relatively few HBsG-negative cases are due to hepatitis B virus, and that hepatitis A virus and non-A, non-B viruses are both important in acute non-B disease.
我们对45例散发性急性病毒性肝炎且乙肝表面抗原（HBsAg）阴性的成年人进行了血清学研究。有2例由乙肝病毒引起，乙肝核心抗原抗体的出现证实了这一点。在其他3例患者中，血清学模式尚无定论。在40例非乙肝病例中，20例为甲型肝炎，20例为非甲非乙肝炎。临床上，甲型肝炎和非甲非乙肝炎无法区分；每组各有1例暴发性疾病。甲型肝炎病例在年轻人中更为常见；非甲非乙肝炎在35岁及以上女性中占主导。流行病学背景总体相似，包括非法自我注射；但4例输血相关病例仅限于非甲非乙肝炎组。我们得出结论，HBsG阴性病例中由乙肝病毒引起的相对较少，甲型肝炎病毒和非甲非乙肝病毒在急性非乙肝疾病中都很重要。
