Wahlqvist P, Reilly M C, Barkun A
AstraZeneca R&D Mölndal, Mölndal, Sweden.
Aliment Pharmacol Ther. 2006 Jul 15;24(2):259-72. doi: 10.1111/j.1365-2036.2006.02996.x.
Gastro-oesophageal reflux disease has wide-ranging effects on patients' lives.
To review systematically the effects of gastro-oesophageal reflux disease on work productivity.
Studies of gastro-oesophageal reflux disease and work productivity were identified in a systematic literature search and their results were valued in US dollars using the human capital method. Work productivity loss was defined as absence from work (absenteeism) plus reduced effectiveness while working (presenteeism).
Eight eligible studies were included. Reported work productivity loss among individuals with gastro-oesophageal reflux disease ranged from 6% to 42% and was primarily because of presenteeism (6-40%) rather than absenteeism (<1% to 7%). Reported losses were greatest in patients experiencing sleep disturbance because of gastro-oesophageal reflux disease, and lowest in individuals from the general population taking appropriate prescription medication. Work productivity impairment correlated with symptom severity and responded to acid-suppressive therapy. Assuming a 40-h working week and average wages in the US, the weekly mean productivity loss per employee with gastro-oesophageal reflux disease can be estimated between 2.4 (62 dollars) and 16.6 h (430 dollars), depending on the population studied.
Gastro-oesophageal reflux disease has a substantial impact on employee productivity, primarily by impairing productivity while working. Further studies are needed to confirm that this impact can be decreased by acid-suppressive therapy.
胃食管反流病对患者的生活有广泛影响。
系统回顾胃食管反流病对工作效率的影响。
通过系统的文献检索确定有关胃食管反流病和工作效率的研究，并使用人力资本法将其结果换算为美元价值。工作效率损失定义为缺勤（旷工）加上工作时效率降低（出勤但效率低）。
纳入八项符合条件的研究。报告的胃食管反流病患者的工作效率损失在6%至42%之间，主要是由于出勤但效率低（6%至40%），而非旷工（<1%至7%）。报告的损失在因胃食管反流病而睡眠障碍的患者中最大，在服用适当处方药的普通人群中最低。工作效率受损与症状严重程度相关，并对抑酸治疗有反应。假设每周工作40小时和美国的平均工资，根据所研究的人群，胃食管反流病员工每周平均生产力损失估计在2.4小时（62美元）至16.6小时（430美元）之间。
胃食管反流病对员工生产力有重大影响，主要是通过损害工作时的生产力。需要进一步研究以证实抑酸治疗可降低这种影响。
