Fernández-Bañares F, Esteve-Comas M, Mañé J, Navarro E, Bertrán X, Cabré E, Bartolí R, Boix J, Pastor C, Gassull M A
Department of Gastroenterology, Research Unit, Hospital Universitari Germans Trias i Pujol, Carretera del Canyet s/n, 08916 Badalona, Spain.
Clin Nutr. 1997 Aug;16(4):177-83. doi: 10.1016/s0261-5614(97)80003-9.
Plasma polyunsaturated fatty acid profile in patients with inflammatory bowel disease is abnormal. We aimed to assess the mucosal fatty acid pattern in patients with ulcerative colitis and Crohn's disease, and in rats with trinitrobenzene-sulfonic acid (TNB) induced colitis.
Fatty acids were measured in colonic mucosa of patients with ulcerative colitis (n = 30), Crohn's disease (n = 21), and healthy controls (n = 13). Likewise, they were assessed in the colonic mucosa of rats with TNB- and sham-colitis.
There was an increase of the end-products (C22:5n3, C22:6n3, C20:4n6, C22:5n6) and a decrease of the precursors (C18:3n3, C18:2n6) of both n3 and n6 polyunsaturated fatty acids in the mucosa of active ulcerative colitis and TNB-colitis. Also, high values of saturated (C16:0, C18:0) and low values of monounsaturated fatty acids (C18:1n9) were observed. Furthermore, the mucosa of active Crohn's disease showed substantial changes in saturated, monounsaturated and essential fatty acids, but not in polyunsaturated fatty acids. Mucosa of patients with inactive disease showed intermediate fatty acid values between the mucosa of active patients and healthy controls.
Colonic inflammation causes a characteristic modification of the mucosal fatty acid profile which appears to be common to different aetiologies and seems to be related to the degree of inflammation.
炎症性肠病患者的血浆多不饱和脂肪酸谱异常。我们旨在评估溃疡性结肠炎和克罗恩病患者以及三硝基苯磺酸（TNB）诱导的结肠炎大鼠的黏膜脂肪酸模式。
测定了溃疡性结肠炎患者（n = 30）、克罗恩病患者（n = 21）和健康对照者（n = 13）结肠黏膜中的脂肪酸。同样，对TNB诱导结肠炎和假手术对照的大鼠结肠黏膜进行了评估。
在活动期溃疡性结肠炎和TNB诱导结肠炎的黏膜中，n3和n6多不饱和脂肪酸的终产物（C22:5n3、C22:6n3、C20:4n6、C22:5n6）增加，前体（C18:3n3、C18:2n6）减少。此外，还观察到饱和脂肪酸（C16:0、C18:0）含量高，单不饱和脂肪酸（C18:1n9）含量低。此外，活动期克罗恩病的黏膜在饱和、单不饱和和必需脂肪酸方面有显著变化，但在多不饱和脂肪酸方面没有变化。非活动期疾病患者的黏膜脂肪酸值介于活动期患者和健康对照者之间。
结肠炎症导致黏膜脂肪酸谱发生特征性改变，这似乎在不同病因中常见，且似乎与炎症程度有关。
