Kuroki F, Iida M, Matsumoto T, Aoyagi K, Kanamoto K, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Dig Dis Sci. 1997 Jun;42(6):1137-41. doi: 10.1023/a:1018873217192.
To determine fatty acid patterns in Crohn's disease, we measured various serum fatty acids by gas chromatography in 20 patients with the disease and compared them with those in 18 healthy controls. All the patients had been free from any nutritional supplementation during preceding six months or had no history of intestinal resection. Eight of the patients were affected in the small bowel only, three in the large bowel only, and the remaining nine in both the small and large bowel. Both serum concentrations and percentages of C20:4n6, C20:5n3, C22:0, C22:6n3, total n3 polyunsaturated fatty acids, and total polyunsaturated fatty acids were lower in the patients than in the controls. Both essential fatty acids (C18:2n6, C18:3n3) and C20:3n9 levels were not different between the two groups. Among nine fatty acids that correlated with the Crohn's disease activity index, C20:5n3 and total n3 polyunsaturated fatty acids showed the most significant negative correlations. These findings suggest that essential fatty acid deficiency rarely occurs in Crohn's disease and also that n3 polyunsaturated fatty acids may be relevant to the activity of the disease.
为了确定克罗恩病患者的脂肪酸模式，我们通过气相色谱法测量了20例该病患者的各种血清脂肪酸，并将其与18名健康对照者的血清脂肪酸进行了比较。所有患者在之前六个月内均未接受任何营养补充，也没有肠道切除术史。其中8例患者仅累及小肠，3例仅累及大肠，其余9例小肠和大肠均受累。患者血清中C20:4n6、C20:5n3、C22:0、C22:6n3、总n3多不饱和脂肪酸和总多不饱和脂肪酸的浓度及百分比均低于对照组。两组间必需脂肪酸（C18:2n6、C18:3n3）和C20:3n9水平无差异。在与克罗恩病活动指数相关的9种脂肪酸中，C20:5n3和总n3多不饱和脂肪酸显示出最显著的负相关。这些发现表明，克罗恩病很少发生必需脂肪酸缺乏，n3多不饱和脂肪酸可能与该病的活动有关。
