Matsusako T, Muramatsu H, Shirahama T, Muramatsu T, Ohi Y
Department of Urology, Faculty of Medicine, Kagoshima University, Japan.
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1218-22. doi: 10.1016/0006-291x(91)92068-u.
Sialyl dimeric Le(x) antigen was expressed in significant portion of transitional cell carcinoma of the human urinary bladder, but not in the normal uroepithelial tissue. Primary tumors with weak or no expression of the antigen scarcely metastasized to lymph nodes, whereas tumors with high levels of antigen expression metastasized frequently. Metastatic lymph nodes expressed the antigen in most cases. Sialyl dimeric Le(x) antigen was mainly located on 60 and 42 KDa glycoproteins. Since a group of cell adhesion molecules, called LECCAMs, recognize a portion of the antigen, the above results strongly suggest that a LECCAM on the surface of host cells recognizes the carbohydrate structure on the glycoprotein, leading to promotion of metastasis.
唾液酸化二聚体Le(x)抗原在人膀胱癌的大部分移行细胞癌中表达，但在正常尿路上皮组织中不表达。该抗原表达弱或无表达的原发性肿瘤很少转移至淋巴结，而抗原高表达的肿瘤则经常发生转移。大多数情况下，转移性淋巴结表达该抗原。唾液酸化二聚体Le(x)抗原主要位于60 kDa和42 kDa的糖蛋白上。由于一组称为LECCAMs的细胞黏附分子可识别该抗原的一部分，上述结果强烈提示宿主细胞表面的一种LECCAM识别糖蛋白上的碳水化合物结构，从而促进转移。
