生物保护剂系统的非弹性中子散射研究
Inelastic neutron scattering study on bioprotectant systems.
作者信息
Magazù S, Migliardo F, Ramirez-Cuesta A J
机构信息
Università di Messina, Dipartimento di Fisica and INFM, PO Box 55, S.ta Sperone C.da Papardo, 98166 Messina, Italy.
出版信息
J R Soc Interface. 2005 Dec 22;2(5):527-32. doi: 10.1098/rsif.2005.0059.
We collected inelastic neutron scattering (INS) spectra of homologous disaccharide (C12H22O11)/H2O mixtures at a very low temperature by using indirect geometry time-of-flight spectrometer TOSCA at the ISIS pulse neutron facility (DRAL, UK). The aim of this work is to investigate the vibrational behaviour of trehalose, maltose and sucrose/H2O mixtures with INS in order to characterize the structural changes induced by these disaccharides on the H2O hydrogen-bonded network. A higher degree of 'crystallinity' for the trehalose/H2O system is observed in the vibrational region corresponding to the ice bending modes. This feature could justify the better cryptobiotic action of trehalose compared with maltose and sucrose. On the other hand, the better bioprotective effectiveness could be explained by the higher destructuring effect of trehalose, emphasized by the analysis of the librational modes region.
我们在英国 ISIS 脉冲中子设施（DRAL）的间接几何飞行时间光谱仪 TOSCA 上，于极低温下收集了同源二糖（C12H22O11）/H2O 混合物的非弹性中子散射（INS）光谱。这项工作的目的是利用 INS 研究海藻糖、麦芽糖和蔗糖/H2O 混合物的振动行为，以表征这些二糖对 H2O 氢键网络引起的结构变化。在对应于冰弯曲模式的振动区域，观察到海藻糖/H2O 系统具有更高程度的“结晶度”。这一特征可以解释海藻糖与麦芽糖和蔗糖相比具有更好的隐生作用。另一方面，更好的生物保护效果可以通过海藻糖更高的去结构化效应来解释，这在转动模式区域的分析中得到了强调。
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