Chatterjee Siddhartha, Chowdhury R G, Khan B
Repose Fertility Clinic, Kolkata.
J Indian Med Assoc. 2006 Feb;104(2):74, 76-7.
Management of male infertility is always a difficult task. In recent years booming of artificial reproductive technologies (ART) has put infertologists and andrologists in front of a million dollar question whether to treat the person or the gametes. A basic andrology laboratory at present has become part and parcel of an infertility clinic. Hence treatment of male infertility has become institutional and collective for clinicians and basic scientists. The basic approach towards management of male infertility includes confirmation of diagnosis and to find out the cause for which pathological, endocrinological and biochemical tests are essential. In this series specific defects causing seminopathy has been found in 18% cases where treatment is straightforward and towards the cause. The main bulk of idiopathic seminal defects (82%) really poses challenge to the infertologists so far management is concerned. In this study commonest seminal defect has been found to be oligoasthenozoospermia which amounts to 63% cases. For medical management purpose drugs commonly used are clomiphene, gonadotrophins, bromocriptine, L-thyroxine, vitamin E, B12, etc. When they fail the main approach remains to be intra-uterine insemination (IUI) and ART eg, in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI).
男性不育症的治疗一直是一项艰巨的任务。近年来，人工生殖技术（ART）的蓬勃发展让不育症专家和男科医生面临一个价值百万美元的问题：是治疗患者还是治疗配子。目前，一个基础男科实验室已成为不育症诊所不可或缺的一部分。因此，对于临床医生和基础科学家来说，男性不育症的治疗已变得具有整体性和集体性。男性不育症治疗的基本方法包括确诊并找出病因，而病理、内分泌和生化检查对此至关重要。在本系列研究中，发现18%的病例存在导致精液病的特定缺陷，对此治疗方法直接且针对病因。就治疗而言，大部分特发性精液缺陷病例（82%）确实给不育症专家带来了挑战。在本研究中，最常见的精液缺陷是少弱畸精子症，占病例总数的63%。出于药物治疗目的，常用的药物有克罗米芬、促性腺激素、溴隐亭、左甲状腺素、维生素E、维生素B12等。当这些药物治疗失败时，主要的治疗方法仍然是宫内人工授精（IUI）和ART，例如体外受精（IVF）和卵胞浆内单精子注射（ICSI）。
