Gordon Grant R J, Bains Jaideep S
Hotchkiss Brain Institute and the Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada.
J Physiol. 2006 Oct 15;576(Pt 2):341-7. doi: 10.1113/jphysiol.2006.110270. Epub 2006 Jul 20.
Alterations in synaptic strength are thought to represent the cellular basis of learning and memory. While such processes appear to be fundamental to all synapses, until recently there has been a relative dearth of information regarding synaptic 'memory' processes in autonomic circuits. Here we examine recent advances in our understanding of plasticity at glutamatergic synapses onto magnocellular neurosecretory cells in the hypothalamus, paying particular attention to the contributions of noradrenaline in coding long-lasting pre- and postsynaptic changes in efficacy. We also highlight recent work demonstrating that glial cells play a crucial role in the induction of long-term potentiation. Based on the work reviewed here, we have a clearer picture of the synaptic and cellular mechanisms that allow autonomic pathways to learn and remember.
突触强度的改变被认为是学习和记忆的细胞基础。虽然这些过程似乎是所有突触的基本特征，但直到最近，关于自主神经回路中突触“记忆”过程的信息相对较少。在这里，我们研究了我们对下丘脑大细胞神经分泌细胞上谷氨酸能突触可塑性理解的最新进展，特别关注去甲肾上腺素在编码突触前和突触后长期效能变化中的作用。我们还强调了最近的研究工作，这些工作表明神经胶质细胞在长时程增强的诱导中起关键作用。基于这里回顾的工作，我们对自主神经通路学习和记忆的突触和细胞机制有了更清晰的认识。
