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Genetics of Natural Populations IX. Temporal Changes in the Composition of Populations of Drosophila Pseudoobscura.自然种群的遗传学IX. 拟暗果蝇种群组成的时间变化
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Reduced variation in the yellow-achaete-scute region in natural populations of Drosophila melanogaster.自然种群中果蝇黄色条纹-触角足区域的变异性降低。
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Selective mechanisms in bacteria.细菌中的选择机制。
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Properties of a neutral allele model with intragenic recombination.具有基因内重组的中性等位基因模型的性质。
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The hitch-hiking effect of a favourable gene.有利基因的搭便车效应。
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Genetic uniformity in two populations of Drosophila melanogaster as revealed by filter hybridization of four-nucleotide-recognizing restriction enzyme digests.通过识别四核苷酸的限制性内切酶消化产物的滤膜杂交揭示的黑腹果蝇两个种群的遗传一致性。
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The "hitchhiking effect" revisited.再探“搭便车效应”。
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10
Restriction-map variation with the yellow-achaete-scute region in five populations of Drosophila melanogaster.黑腹果蝇五个种群中黄色-无刚毛-小盾片区域的限制性图谱变异
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由于选择导致果蝇第四条染色体上缺乏多态性。

Lack of polymorphism on the Drosophila fourth chromosome resulting from selection.

作者信息

Berry A J, Ajioka J W, Kreitman M

机构信息

Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544.

出版信息

Genetics. 1991 Dec;129(4):1111-7. doi: 10.1093/genetics/129.4.1111.

DOI:10.1093/genetics/129.4.1111
PMID:1686006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1204775/
Abstract

Evolutionary processes can be inferred from comparisons of intraspecific polymorphism and interspecific divergence. We sequenced a 1.1-kb fragment of the cubitus interruptus Dominant (ciD) locus located on the nonrecombining fourth chromosome for ten natural lines of Drosophila melanogaster and nine of Drosophila simulans. We found no polymorphism within D. melanogaster and a single polymorphism within D. simulans; divergence between the species was about 5%. Comparison with the alcohol dehydrogenase gene and its two flanking regions in D. melanogaster, for which comparable data are available, revealed a statistically significant departure from neutrality in all three tests. This lack of polymorphism in the ciD locus may reflect recent positive selective sweeps on the fourth chromosome with extreme hitchhiking generated by the lack of recombination. By simulation, we estimate there to be a 50% chance that the selective sweeps occurred within the past 30,000 years in D. melanogaster and 75,000 in D. simulans.

摘要

进化过程可以通过种内多态性和种间差异的比较来推断。我们对位于非重组第四染色体上的肘脉中断显性（ciD）基因座的1.1kb片段进行了测序，该片段来自10个黑腹果蝇自然品系和9个拟果蝇自然品系。我们在黑腹果蝇中未发现多态性，在拟果蝇中发现了一个多态性；两个物种之间的差异约为5%。与黑腹果蝇中可获得可比数据的乙醇脱氢酶基因及其两个侧翼区域进行比较，发现在所有三项测试中均有统计学上显著偏离中性的情况。ciD基因座中这种多态性的缺乏可能反映了第四染色体上近期的正向选择扫荡，由于缺乏重组而产生了极端的搭便车效应。通过模拟，我们估计在黑腹果蝇中，有50%的可能性选择扫荡发生在过去30000年内，在拟果蝇中为75000年内。