Hintzen R Q, van den Born L I
MS Centre, Department of Neurology, Erasmus University Medical School, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
J Neurol Neurosurg Psychiatry. 2006 Dec;77(12):1373-5. doi: 10.1136/jnnp.2006.090415. Epub 2006 Jul 25.
The case of a 30-year-old woman who had two episodes of photopsia along with sudden-onset monocular visual field defects, developing into bilateral tunnel vision within 4 years, is reported. She also had episodes of a right hemiparesis and right-sided hypoaesthesia, accompanied by severe fatigue. This patient fulfilled the criteria for both clinically definite multiple sclerosis and acute zonal occult outer retinopathy (AZOOR). AZOOR can have an onset with monocular visual field loss, and can be distinguished from optic neuritis. In addition, some observations suggest common neuropathological and inflammatory mechanisms between multiple sclerosis and AZOOR.
报告了一名30岁女性的病例，该患者出现两次闪光幻觉，同时伴有突发的单眼视野缺损，4年内发展为双侧管状视野。她还出现过右侧偏瘫和右侧感觉减退发作，并伴有严重疲劳。该患者符合临床确诊的多发性硬化症和急性区域性隐匿性外层视网膜病变（AZOOR）的标准。AZOOR可表现为单眼视野丧失起病，且可与视神经炎相鉴别。此外，一些观察结果提示多发性硬化症和AZOOR之间存在共同的神经病理和炎症机制。
