Mason Nicholas J, Jenkins Alicia J, Best James D, Rowley Kevin G
The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, Victoria, Australia.
Eur J Cardiovasc Prev Rehabil. 2006 Aug;13(4):598-603. doi: 10.1097/01.hjr.0000216546.07432.b2.
The role of exercise in preventing cardiovascular disease (CVD) has been well documented. To determine whether this benefit could be related to effects on vascular endothelial function and vessel wall elasticity, thereby preserving arterial compliance, we examined the relationship between habitual exercise and arterial compliance as measured by pulse wave analysis.
A cross-sectional study of healthy volunteers and patients with type 1 diabetes.
Non-diabetic individuals not taking cholesterol or blood pressure-lowering medication (n=176) and patients with type 1 diabetes (n=105), aged 17-70 years, were recruited. Small and large artery compliance and other haemodynamic variables were measured using the PulseWave CR-2000 cardiovascular profiling system. A questionnaire was completed to assess the frequency of physical activity.
In multivariate analysis, undertaking three or more episodes of vigorous activity per week was associated with having a 1 unit greater small artery compliance, independent of age, sex, height, diabetes status and blood pressure. The effect was especially marked in non-diabetic women.
The results support other findings that regular physical activity protects against CVD, through the preservation of vascular compliance.
运动在预防心血管疾病（CVD）中的作用已有充分记录。为了确定这种益处是否与对血管内皮功能和血管壁弹性的影响有关，从而保持动脉顺应性，我们通过脉搏波分析研究了习惯性运动与动脉顺应性之间的关系。
对健康志愿者和1型糖尿病患者的横断面研究。
招募了年龄在17 - 70岁之间、未服用胆固醇或降压药物的非糖尿病个体（n = 176）和1型糖尿病患者（n = 105）。使用PulseWave CR - 2000心血管分析系统测量小动脉和大动脉顺应性以及其他血流动力学变量。完成一份问卷以评估身体活动的频率。
在多变量分析中，每周进行三次或更多次剧烈活动与小动脉顺应性增加1个单位相关，且独立于年龄、性别、身高、糖尿病状态和血压。这种效应在非糖尿病女性中尤为明显。
研究结果支持其他研究发现，即规律的体育活动通过保持血管顺应性来预防心血管疾病。
