Skiveren Jette, Mikkelsen Maria Rudkjaer, Daugbjerg Helle, Wulf Hans Christian
Department of Dermatology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen 2400, Denmark.
J Skin Cancer. 2012;2012:825095. doi: 10.1155/2012/825095. Epub 2012 Dec 20.
Background. Advanced basal cell carcinoma (BCC) is often treated by surgery or X-ray therapy. The consequences of X-ray therapy on the patients' health-related quality-of-life (HRQOL) have so far not been described. Objectives. To quantify quality of life in BCC patients before and after X-ray therapy compared with matched healthy controls. Materials. Twenty-five patients (mean age 69) with BCC completed the Dermatology Life Quality Index (DLQI) before and two weeks and three months after X-ray therapy and their results were compared with the DLQI scores for 25 matched controls. Results. Compared to the healthy controls the patients' DLQI score was significantly higher before and 2 weeks after X-ray therapy (P = 0.005; P = 0.000). The patients' DLQI score decreased significantly from baseline to three months after X-ray therapy (P = 0.024), when it became similar to that of the healthy controls (P = 0.819). Three months after X-ray therapy eight patients had no skin reactions, 11 had slight atrophy, pigmentation change, and/or some hair loss, four had patch atrophy, moderate telangiectasia, and/or total hair loss. Conclusions. BCC has a negative effect on patients' quality of life. The study shows that HRQOL normalises shortly after X-ray therapy, despite minor skin manifestations.
背景。晚期基底细胞癌（BCC）通常采用手术或X线治疗。迄今为止，尚未描述X线治疗对患者健康相关生活质量（HRQOL）的影响。目的。量化X线治疗前后BCC患者的生活质量，并与匹配的健康对照进行比较。材料。25例BCC患者（平均年龄69岁）在X线治疗前、治疗后两周和三个月完成了皮肤病生活质量指数（DLQI），并将其结果与25例匹配对照者的DLQI评分进行比较。结果。与健康对照相比，患者在X线治疗前和治疗后2周的DLQI评分显著更高（P = 0.005；P = 0.000）。从基线到X线治疗后三个月患者DLQI评分显著下降（P = 0.024），此时与健康对照者的评分相似（P = 0.819）。X线治疗后三个月时，8例患者无皮肤反应，11例有轻微萎缩、色素沉着改变和/或轻度脱发；4例有片状萎缩、中度毛细血管扩张和/或全秃。结论BCC对患者生活质量有负面影响；研究表明，尽管有轻微皮肤表现，但X线治疗后不久HRQOL即恢复正常。
