Luijsterburg Martijn S, Noom Maarten C, Wuite Gijs J L, Dame Remus Th
Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit, Amsterdam, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands.
J Struct Biol. 2006 Nov;156(2):262-72. doi: 10.1016/j.jsb.2006.05.006. Epub 2006 Jun 3.
The bacterial genome is folded into a compact structure called the nucleoid. Considerable compaction of the DNA molecule is required in order to reduce its volume below that of the cell. Several mechanisms, such as molecular crowding and DNA supercoiling contribute to the compactness of the nucleoid. Besides these mechanisms, a number of architectural proteins associate with the chromosomal DNA and cause it to fold into a compact structure by bridging, bending or wrapping DNA. In this review, we provide an overview of the major nucleoid-associated proteins from a structural perspective and we discuss their possible roles in dynamically shaping the bacterial nucleoid.
细菌基因组折叠成一种称为类核的致密结构。为了将DNA分子的体积减小到低于细胞的体积，需要对其进行相当程度的压缩。诸如分子拥挤和DNA超螺旋等几种机制有助于类核的致密性。除了这些机制外，许多结构蛋白与染色体DNA结合，并通过桥接、弯曲或缠绕DNA使其折叠成致密结构。在本综述中，我们从结构角度概述了主要的类核相关蛋白，并讨论了它们在动态塑造细菌类核中的可能作用。
