Hilsinger R L, Adour K K, Doty H E
Ann Otol Rhinol Laryngol. 1975 Jul-Aug;84(4 Pt 1):433-42. doi: 10.1177/000348947508400402.
The records of 42 women with Bell's palsy during pregnancy, and of 91 nonpregnant women, whose dats of onset of Bell's palsy and of the preceding menstrual cycle were precisely known, were studied for factors that might show relation between pregnancy or the menstrual cycle and Bell's palsy. Of the 42 cases in pregnancy, 31 occurred in the third trimester, five in the first two weeks postpartum, and six in the first two trimesters combined. Our calculated frequency of Bell's palsy in pregnant women is 45.1/100,000 births; for nonpregnant women of the same age group the calculated incidence is 17.4/100,000 per year. No causative relation was found between toxemia, hypertension or primigravidity, and Bell's palsy. Over 60% of the cases in nonpregnant women occurred in the first 14 days of the menstrual cycle with peaks on the first and seventh days and near ovulation. No clear evidence for an etiologic relationship was seen with edema or hormonal changes in either pregnancy or the menstrual cycle. A number of factors in pregnancy and the menstrual cycle suggested an etiologic role for herpes simplex virus reactivation in Bell's palsy. There was no evidence that prednisone treatment is contraindicated during pregnancy.
对42例孕期患贝尔麻痹的女性以及91例非孕期女性的记录进行了研究，这些女性贝尔麻痹的发病日期以及之前月经周期的日期均确切已知，旨在探寻可能表明妊娠或月经周期与贝尔麻痹之间存在关联的因素。在42例孕期病例中，31例发生在孕晚期，5例发生在产后前两周，6例发生在孕早期和孕中期合并阶段。我们计算得出的孕妇贝尔麻痹发病率为每10万例分娩中有45.1例；对于同一年龄组的非孕期女性，计算得出的发病率为每年每10万例中有17.4例。未发现子痫、高血压或初孕与贝尔麻痹之间存在因果关系。非孕期女性中超过60%的病例发生在月经周期的前14天，在第一天和第七天以及接近排卵期时出现高峰。在妊娠或月经周期中，未发现水肿或激素变化与病因之间有明确证据。妊娠和月经周期中的一些因素表明单纯疱疹病毒再激活在贝尔麻痹中可能起病因作用。没有证据表明孕期禁忌使用泼尼松治疗。
