Baune Bernhard T, Suslow Thomas, Arolt Volker, Berger Klaus
Department of Psychiatry, University of Muenster,
J Psychiatr Res. 2007 Apr-Jun;41(3-4):247-54. doi: 10.1016/j.jpsychires.2006.06.004. Epub 2006 Aug 2.
Aim of this study was to examine the association of symptom dimensions of depressive symptoms and cognitive functioning in the elderly. In a population-based study with 365 participants 65-83 years of age, dimensions of depressive symptoms were assessed with the four subscales of the CES-D-score and standardized cognitive tests assessing attention, memory, cognitive speed, and motor speed were performed. Compared to men, women scored significantly higher on the subscales for depressed affect and somatic complaints. Older participants had a significantly higher score for interpersonal difficulties. Participants with lower education had higher scores on all four psychological dimensions of depressive symptoms than those with high education (only significant for depressive affect). Individuals scoring high on CES-D subscales for depressive affect and somatic complaints had statistically significant (after Bonferroni adjustment) lower scores in attention and motor function in multivariate analyses. No significant associations between the symptom dimensions of positive affect and interpersonal difficulties with any of the cognitive tests were found in univariate and multivariate analyses (after Bonferroni adjustment). Our findings suggest specific patterns in the relationships between symptom dimensions of depressive symptoms and cognitive dysfunction in the general elderly population. This novel approach might be useful in addressing the heterogeneity of cognitive impairment in depression and in predicting cognitive outcome in depression.
本研究的目的是探讨老年人群中抑郁症状的症状维度与认知功能之间的关联。在一项基于人群的研究中，有365名年龄在65至83岁之间的参与者，使用CES-D得分的四个子量表评估抑郁症状维度，并进行了评估注意力、记忆力、认知速度和运动速度的标准化认知测试。与男性相比，女性在抑郁情绪和躯体不适子量表上的得分显著更高。年龄较大的参与者在人际困难方面得分显著更高。受教育程度较低的参与者在抑郁症状的所有四个心理维度上的得分均高于受教育程度高的参与者（仅在抑郁情绪方面具有显著性）。在多变量分析中，CES-D抑郁情绪和躯体不适子量表得分高的个体在注意力和运动功能方面的得分具有统计学显著性降低（经Bonferroni校正后）。在单变量和多变量分析中（经Bonferroni校正后）未发现积极情绪和人际困难的症状维度与任何认知测试之间存在显著关联。我们的研究结果表明了老年普通人群中抑郁症状的症状维度与认知功能障碍之间关系的特定模式。这种新方法可能有助于解决抑郁症中认知障碍的异质性问题，并预测抑郁症的认知结果。
