Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA; Department of Neuroscience, University of Florida, Gainesville, FL, USA.
Psychiatry Res Neuroimaging. 2017 Oct 30;268:9-14. doi: 10.1016/j.pscychresns.2017.08.002. Epub 2017 Aug 15.
We recently reported age-related increases in left precuneus cortical thickness (CT) in older adults with elevated total depressive symptoms. However, it is unclear whether abnormalities in precuneus surface area (SA) are also evident and whether specific symptom dimensions of depression moderated age effects on these measurements. Seventy-three adults completed the Beck Depression Inventory - 2nd edition (BDI-II) and underwent structural neuroimaging. Measures of CT and SA were extracted from the right and left precuneus via FreeSurfer. Regression models included regions of interest as dependent variables, with age, BDI-II subscale scores (e.g., affective, cognitive, and somatic symptoms), and their interactions as independent variables, controlling for mean hemispheric thickness (for CT) or total intracranial volume (for SA). A significant age × somatic symptom interaction was found for left precuneus CT, such that elevated levels of somatic symptoms were significantly associated with age-related cortical thinning. No depressive symptom dimensions moderated the relationship between age and SA, suggesting that CT may be a more sensitive measure of brain abnormalities in middle-aged to older adults with depressive symptoms.
我们最近报道称，在总抑郁症状较高的老年人中，左楔前叶皮质厚度（CT）随年龄增长而增加。然而，楔前叶表面积（SA）是否也存在异常尚不清楚，以及抑郁的特定症状维度是否调节了这些测量指标的年龄效应。73 名成年人完成了贝克抑郁量表-第二版（BDI-II），并进行了结构神经影像学检查。通过 FreeSurfer 从右侧和左侧楔前叶提取 CT 和 SA 的测量值。回归模型将感兴趣区域作为因变量，年龄、BDI-II 子量表评分（例如，情感、认知和躯体症状）及其交互作用作为自变量，同时控制半球平均厚度（用于 CT）或总颅内体积（用于 SA）。发现左侧楔前叶 CT 存在年龄×躯体症状的显著交互作用，表明躯体症状水平升高与年龄相关的皮质变薄显著相关。抑郁症状的任何维度都没有调节年龄与 SA 之间的关系，这表明 CT 可能是一种更敏感的测量指标，可用于评估有抑郁症状的中年至老年人大脑异常。
