间日疟原虫环子孢子蛋白上T细胞表位的鉴定
Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax.
作者信息
George F W, Law J L, Rich K A, Martin W J
机构信息
Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.
出版信息
Infect Immun. 1990 Feb;58(2):575-8. doi: 10.1128/iai.58.2.575-578.1990.
Abstract
A series of overlapping peptides, representing sequences in the vicinity of region II on the Plasmodium vivax circumsporozoite protein, was synthesized. One of the peptides (PV-23), a 20-mer containing the 6 C-terminal amino acids of region II, was found to evoke an in vitro T-cell proliferative response in spleen cells from C3Hf (H-2km2) mice immunized with the peptide. These results demonstrate that PV-23 contains a T-cell epitope. To our knowledge, this is the first report of a T-cell epitope on the circumsporozoite protein of P. vivax.
摘要
合成了一系列重叠肽，这些肽代表间日疟原虫环子孢子蛋白上区域II附近的序列。其中一种肽（PV-23）是一个含有区域II的6个C末端氨基酸的20肽，在用该肽免疫的C3Hf（H-2km2）小鼠的脾细胞中发现它能引发体外T细胞增殖反应。这些结果表明PV-23含有一个T细胞表位。据我们所知，这是关于间日疟原虫环子孢子蛋白上T细胞表位的首次报道。
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