间日疟原虫环子孢子蛋白上T细胞表位的鉴定
Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax.
作者信息
George F W, Law J L, Rich K A, Martin W J
机构信息
Department of Pathology, University of Southern California School of Medicine, Los Angeles 90033.
出版信息
Infect Immun. 1990 Feb;58(2):575-8. doi: 10.1128/iai.58.2.575-578.1990.
Abstract
A series of overlapping peptides, representing sequences in the vicinity of region II on the Plasmodium vivax circumsporozoite protein, was synthesized. One of the peptides (PV-23), a 20-mer containing the 6 C-terminal amino acids of region II, was found to evoke an in vitro T-cell proliferative response in spleen cells from C3Hf (H-2km2) mice immunized with the peptide. These results demonstrate that PV-23 contains a T-cell epitope. To our knowledge, this is the first report of a T-cell epitope on the circumsporozoite protein of P. vivax.
摘要
合成了一系列重叠肽，这些肽代表间日疟原虫环子孢子蛋白上区域II附近的序列。其中一种肽（PV-23）是一个含有区域II的6个C末端氨基酸的20肽，在用该肽免疫的C3Hf（H-2km2）小鼠的脾细胞中发现它能引发体外T细胞增殖反应。这些结果表明PV-23含有一个T细胞表位。据我们所知，这是关于间日疟原虫环子孢子蛋白上T细胞表位的首次报道。
相似文献
1
Identification of a T-cell epitope on the circumsporozoite protein of Plasmodium vivax.间日疟原虫环子孢子蛋白上T细胞表位的鉴定
Infect Immun. 1990 Feb;58(2):575-8. doi: 10.1128/iai.58.2.575-578.1990.
2
3
Identification of epitopes within the circumsporozoite protein of Plasmodium vivax recognized by murine T lymphocytes.
Exp Parasitol. 1991 Apr;72(3):271-7. doi: 10.1016/0014-4894(91)90146-n.
4
Human recognition of T cell epitopes on the Plasmodium vivax circumsporozoite protein.人类对间日疟原虫环子孢子蛋白上T细胞表位的识别。
J Immunol. 1992 Jun 15;148(12):3986-90.
5
Fine epitope specificity of antibodies to region II of the Plasmodium vivax circumsporozoite protein correlates with ability to bind recombinant protein and sporozoites.针对间日疟原虫环子孢子蛋白II区抗体的精细表位特异性与结合重组蛋白及子孢子的能力相关。
Acta Trop. 1997 May 15;65(2):59-80. doi: 10.1016/s0001-706x(97)00648-7.
6
Antigenicity and immunogenicity of multiple antigen peptides (MAP) containing P. vivax CS epitopes in Aotus monkeys.含有间日疟原虫环子孢子蛋白（CS）表位的多抗原肽（MAP）在夜猴中的抗原性和免疫原性
Parasite Immunol. 1997 Apr;19(4):161-70. doi: 10.1046/j.1365-3024.1997.d01-193.x.
7
Life-spans of human T-cell responses to determinants from the circumsporozoite proteins of Plasmodium falciparum and Plasmodium vivax.人类对恶性疟原虫和间日疟原虫环子孢子蛋白决定簇的T细胞反应的寿命。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6118-22. doi: 10.1073/pnas.91.13.6118.
8
Plasmodium vivax promiscuous T-helper epitopes defined and evaluated as linear peptide chimera immunogens.间日疟原虫混杂型T辅助表位被定义并评估为线性肽嵌合免疫原。
Infect Immun. 2002 Jul;70(7):3479-92. doi: 10.1128/IAI.70.7.3479-3492.2002.
9
10
Induction of Multifunctional Broadly Reactive T Cell Responses by a Plasmodium vivax Circumsporozoite Protein Recombinant Chimera.间日疟原虫环子孢子蛋白重组嵌合体诱导多功能广泛反应性T细胞应答
Infect Immun. 2015 Sep;83(9):3749-61. doi: 10.1128/IAI.00480-15. Epub 2015 Jul 13.
引用本文的文献
1
Antibody response of humans to the circumsporozoite protein of Plasmodium vivax.人类对间日疟原虫环子孢子蛋白的抗体反应。
Infect Immun. 1991 Aug;59(8):2836-8. doi: 10.1128/iai.59.8.2836-2838.1991.
本文引用的文献
1
Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development.鼠疟原虫疫苗的功效：对人类疫苗开发的启示。
Science. 1987 Apr 24;236(4800):453-6. doi: 10.1126/science.3551073.
2
Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine.间日疟原虫一种抗原在酵母中的表达，该抗原可能用于人类疟疾疫苗。
J Exp Med. 1987 Apr 1;165(4):1160-71. doi: 10.1084/jem.165.4.1160.
3
In vivo testing of subunit vaccines against malaria sporozoites using a rodent system.使用啮齿动物系统对疟疾子孢子亚单位疫苗进行体内测试。
Proc Natl Acad Sci U S A. 1987 Dec;84(23):8647-51. doi: 10.1073/pnas.84.23.8647.
4
Synthetic peptide vaccine confers protection against murine malaria.合成肽疫苗可提供针对鼠疟的保护。
J Exp Med. 1987 Nov 1;166(5):1591-6. doi: 10.1084/jem.166.5.1591.
5
Genetic restriction of the murine humoral response to a recombinant Plasmodium vivax circumsporozoite protein.小鼠对重组间日疟原虫环子孢子蛋白体液反应的遗传限制
Eur J Immunol. 1988 Jul;18(7):1119-22. doi: 10.1002/eji.1830180722.
6
Does biased gene conversion influence polymorphism in the circumsporozoite protein-encoding gene of Plasmodium vivax?有偏向性的基因转换是否会影响间日疟原虫环子孢子蛋白编码基因的多态性？
Proc Natl Acad Sci U S A. 1988 Nov;85(21):8102-6. doi: 10.1073/pnas.85.21.8102.
7
Molecular characterization of the C3HfB/HeN H-2Kkm2 mutation. Implications for the molecular basis of alloreactivity.C3HfB/HeN H-2Kkm2突变的分子特征。对同种异体反应性分子基础的影响。
J Exp Med. 1988 Nov 1;168(5):1781-800. doi: 10.1084/jem.168.5.1781.
8
Safety and efficacy of a recombinant DNA Plasmodium falciparum sporozoite vaccine.重组DNA恶性疟原虫子孢子疫苗的安全性与有效性
Lancet. 1987 Jun 6;1(8545):1277-81. doi: 10.1016/s0140-6736(87)90540-x.
9
Human lymphocyte proliferative response to a sporozoite T cell epitope correlates with resistance to falciparum malaria.人类淋巴细胞对疟原虫T细胞表位的增殖反应与对恶性疟原虫疟疾的抗性相关。
J Immunol. 1989 Feb 15;142(4):1299-303.
10
A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules.一种与大多数小鼠和人类MHC II类分子相关联而被识别的疟疾T细胞表位。
Nature. 1988;336(6201):778-80. doi: 10.1038/336778a0.
Zotero 插件